DK-AH 269
DK-AH 269 structure
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Common Name | DK-AH 269 | ||
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| CAS Number | 186097-54-1 | Molecular Weight | 519.07300 | |
| Density | N/A | Boiling Point | 655.7ºC at 760 mmHg | |
| Molecular Formula | C28H39ClN2O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 350.4ºC | |
Use of DK-AH 269Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.Target: HCN Channel blockerCilobradine is a HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, Cilobradine inhibits WT mHCN2 channel current by 86 ± 2% (n = 5). In contrast, I432A and A425G channel currents were only reduced by 14 ± 1% (n = 4) and 19 ± 2% (n = 8), respectively, by this concentration of Cilobradine. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM Cilobradine (8 ± 2% inhibition; n = 4). |
| Name | Cilobradine hydrochloride |
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| Synonym | More Synonyms |
| Description | Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.Target: HCN Channel blockerCilobradine is a HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, Cilobradine inhibits WT mHCN2 channel current by 86 ± 2% (n = 5). In contrast, I432A and A425G channel currents were only reduced by 14 ± 1% (n = 4) and 19 ± 2% (n = 8), respectively, by this concentration of Cilobradine. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM Cilobradine (8 ± 2% inhibition; n = 4). |
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| Related Catalog | |
| References |
| Boiling Point | 655.7ºC at 760 mmHg |
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| Molecular Formula | C28H39ClN2O5 |
| Molecular Weight | 519.07300 |
| Flash Point | 350.4ºC |
| Exact Mass | 518.25500 |
| PSA | 60.47000 |
| LogP | 4.28070 |
| Vapour Pressure | 1.96E-17mmHg at 25°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine.
Eur. J. Pharmacol. 478 , 161-171, (2003) The action of the bradycardiac agents, cilobradine (DK-AH269) and zatebradine (UL-FS49), on the cardiac pacemaker current (If) was investigated on short Purkinje fibres from sheep hearts, using the tw... |
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Bradycardic and proarrhythmic properties of sinus node inhibitors.
Mol. Pharmacol. 69 , 1328-1337, (2006) Sinus node inhibitors reduce the heart rate presumably by blocking the pacemaker current If in the cardiac conduction system. This pacemaker current is carried by four hyperpolarization-activated, cyc... |
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Use-dependent block of Ih in mouse dorsal root ganglion neurons by sinus node inhibitors.
Br. J. Pharmacol. 125 , 741-750, (1998) 1. The sinus node inhibitors UL FS 49 and DK-AH 269 reduce heart rate by slowing diastolic depolarization rate in the sino-atrial (SA) node, which might originate from the use-dependent blockade of a ... |
| DK-AH 269 |
| (S)-(+)-7,8-Dimethoxy-3-[[1-(2-(3,4-dimethoxyphenyl)ethyl)-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride |
| 3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one,hydrochloride |
| DK-AH 269 |
| Cilobradine (hydrochloride) |