(E)-3-(4-Hydroxy-3,5-dimethoxyphenyl)acrylic acid

(E)-3-(4-Hydroxy-3,5-dimethoxyphenyl)acrylic acid Structure
(E)-3-(4-Hydroxy-3,5-dimethoxyphenyl)acrylic acid structure
Common Name (E)-3-(4-Hydroxy-3,5-dimethoxyphenyl)acrylic acid
CAS Number 7362-37-0 Molecular Weight 224.21000
Density N/A Boiling Point N/A
Molecular Formula C11H12O5 Melting Point N/A
MSDS N/A Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

Methionine oxidation accelerates the aggregation and enhances the neurotoxicity of the D178N variant of the human prion protein.

Biochim. Biophys. Acta 1842(12 Pt A) , 2345-56, (2014)

The D178N mutation of the prion protein (PrP) results in the hereditary prion disease fatal familial insomnia (FFI). Little is known regarding the effects of methionine oxidation on the pathogenesis of D178N-associated FFI. In the present study, we found that...

Dimethyl sulphoxide and Ca2+ stimulate assembly of Vibrio cholerae FtsZ.

Biochimie 105 , 64-75, (2014)

We cloned, overexpressed and purified Vibrio cholerae FtsZ protein for the first time. We used several complementary techniques to probe and compare the comparative assembly properties of recombinant Vibrio cholerae FtsZ (VcFtsZ) and Escherichia coli FtsZ (Ec...

Antimicrobial activity of natural products from the flora of Northern Ontario, Canada.

Pharm. Biol. 53(6) , 800-6, (2015)

The number of multidrug resistant (MDR) microorganisms is increasing and the antimicrobial resistance expressed by these pathogens is generating a rising global health crisis. In fact, there are only a few antimicrobial agents left that can be used against MD...

Isolation and characterization of feruloylated arabinoxylan oligosaccharides from the perennial cereal grain intermediate wheat grass (Thinopyrum intermedium).

Carbohydr. Res. 407 , 16-25, (2015)

In comparison to the annual grain crops dominating current agricultural production, perennial grain species require fewer chemical and energy inputs and improve soil health and erosion control. The possibility for producing sustainable grain harvests from mar...

Analysis of different European hazelnut (Corylus avellana L.) cultivars: authentication, phenotypic features, and phenolic profiles.

J. Agric. Food Chem. 62(26) , 6236-46, (2014)

Hazelnuts exhibit functional properties due to their content in fatty acids and phenolic compounds that could positively affect human health. The food industry requires precise traits for morphological, chemical, and physical kernel features so that some cult...

Investigating the potential of under-utilised plants from the Asteraceae family as a source of natural antimicrobial and antioxidant extracts.

Food Chem. 161 , 79-86, (2014)

Antimicrobial properties of ethanol and water extracts from eight Asteraceae species were investigated against three Gram positive (Staphylococcus aureus, MRSA and Bacillus cereus) and two Gram negative (Escherichia coli and Salmonella typhimurium) bacterial ...

A novel coumarin-quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death.

Mol. Carcinog. 54(3) , 229-41, (2015)

Cell division cycle (CDC) 25 proteins are key phosphatases regulating cell cycle transition and proliferation by regulating CDK/cyclin complexes. Overexpression of these enzymes is frequently observed in cancer and is related to aggressiveness, high-grade tum...

LDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153-421): design, synthesis and biochemical evaluation.

Eur. J. Med. Chem. 92 , 890-907, (2015)

High level of Low Density Lipoprotein-Cholesterol (LDL-C) in circulation in the blood is associated with an elevated risk of cardiovascular disease (CVD) and stroke. Currently the statin drugs which inhibit the enzyme HMG-CoA reductase responsible for cholest...

A protective chimeric antibody to tick-borne encephalitis virus.

Vaccine 32(29) , 3589-94, (2014)

The efficiency of several mouse monoclonal antibodies (mAbs) specific to the tick-borne encephalitis virus (TBEV) glycoprotein E in post-exposure prophylaxis was assessed, and mAb14D5 was shown to be the most active of all those studied. It was proven that th...

Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for 2009-2010.

Mass Spectrom. Rev. 34(3) , 268-422, (2015)

This review is the sixth update of the original article published in 1999 on the application of MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2010. General aspects such as theo...