Diacetolol
Diacetolol structure
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Common Name | Diacetolol | ||
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| CAS Number | 22568-64-5 | Molecular Weight | 308.37 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 548.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H24N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 285.7±30.1 °C | |
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Using supported liquid extraction together with cellobiohydrolase chiral stationary phases-based liquid chromatography with tandem mass spectrometry for enantioselective determination of acebutolol and its active metabolite diacetolol in spiked human plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(3) , 173-80, (2009) A high through-put, sensitive, and enantioselective LC-MS/MS-based bioanalytical method was developed and validated for the simultaneous determination of individual acebutolol (AC) and its active metabolite-diacetolol (DC) enantiomers in human plasma using ce... |
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Acebutolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects.
Pharmacotherapy 6(2) , 45-63, (1986) Acebutolol is a new hydrophilic, cardioselective beta-adrenergic-blocking agent that possesses partial agonist and membrane-stabilizing activities. In the treatment of mild to moderate essential hypertension, once-daily acebutolol as monotherapy provides effe... |
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Preliminary study of the disposition in man of acebutolol and its metabolite, diacetolol, using a new stereoselective hplc method.
J. Pharm. Pharmacol. 36(4) , 276-7, (1984) A new stereospecific hplc method that is capable of simultaneously quantitating the S-(-)- and R-(+)-enantiomers of acebutolol and its major metabolite, diacetolol, in plasma and urine, is described. When applied to the assay of biological fluids collected du... |
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Lack of effect of liver disease on the pharmacokinetics of acebutolol and diacetolol: a single dose study.
Biopharm. Drug Dispos. 6(2) , 131-7, (1985) The pharmacokinetics of acebutolol and its major metabolite, diacetolol, following a single 400 mg oral dose, were investigated in patients with liver disease. No significant differences were found in any of the parameters measured. |
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Enantioselective high performance liquid chromatographic assay of acebutolol and its active metabolite diacetolol in human serum.
Chirality 11(4) , 267-71, (1999) A stereoselective direct liquid chromatographic method for assay of the enantiomers of the beta-adrenergic blocker acebutolol (AC) and its active metabolite, diacetolol (DC), in human serum was developed. The assay is based on extraction with ethyl acetate an... |
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Displacement of [3H]dihydroalprenolol binding from rat heart and lung by acebutolol, diacetolol and D-diacetolol.
J. Pharm. Pharmacol. 35(3) , 198-9, (1983)
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Acebutolol and oral surgery: plasma levels following a single oral dose.
Ann. R. Coll. Surg. Engl. 67(2) , 124-6, (1985) Twenty eight patients were randomly allocated into treatment or placebo groups. The treatment group received a single 400 mg oral dose of acebutolol, the placebo group an identical inert prepation. A blood sample from each patient was subsequently analysed fo... |
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Pharmacokinetics of acebutolol and its main metabolite, diacetolol after oral administration of acebutolol in rabbits with carbon tetrachloride-induced hepatic failure.
Arch. Pharm. Res. 25(4) , 541-5, (2002) Pharmacokinetic characteristics of acebutolol and its main metabolite, diacetolol, following a single 10 mg/kg oral dose, were investigated in rabbits with carbon tetrachloride-induced hepatic failure. Plasma concentrations of acebutolol and diacetolol were d... |
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New drugs: beta blockers and sympathomimetics.
Br. Med. J. (Clin. Res. Ed.) 286(6375) , 1439, (1983)
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High-performance liquid chromatographic determination of diacetolol enantiomers.
J. Chromatogr. A. 533 , 300-3, (1990)
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