Biopharmaceutics & Drug Disposition 1985-01-01

Lack of effect of liver disease on the pharmacokinetics of acebutolol and diacetolol: a single dose study.

R Zaman, D B Jack, M R Wilkins, M J Kendall

Index: Biopharm. Drug Dispos. 6(2) , 131-7, (1985)

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Abstract

The pharmacokinetics of acebutolol and its major metabolite, diacetolol, following a single 400 mg oral dose, were investigated in patients with liver disease. No significant differences were found in any of the parameters measured.