Dextrothyroxine
Dextrothyroxine structure
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Common Name | Dextrothyroxine | ||
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| CAS Number | 51-49-0 | Molecular Weight | 776.870 | |
| Density | 2.6±0.1 g/cm3 | Boiling Point | 576.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C15H11I4NO4 | Melting Point | 225ºC | |
| MSDS | N/A | Flash Point | 302.3±30.1 °C | |
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Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
J. Med. Chem. 50 , 5589-99, (2007) Transthyretin (TTR), a tetrameric thyroxine (T4) carrier protein, is associated with a variety of amyloid diseases. In this study, we explore the potential of biphenyl ethers (BPE), which are shown to interact with a high affinity to its T4 binding site there... |
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Maintenance of brain thyroid hormone level during peripheral hypothyroid condition in adult rat.
Life Sci. 79(15) , 1450-5, (2006) Thyroid hormones are essential for normal functioning of adult mammalian brain. The present investigation deals with the understanding of the time course of thyroid hormone homeostasis in adult rat brain. Animals were rendered hypothyroid by PTU injections (2... |
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Dextrothyroxine in the treatment of generalized thyroid hormone resistance in a boy homozygous for a defect in the T3 receptor.
Thyroid 2(1) , 15-9, (1992) The dextroisomer of thyroxine (D-T4) has been shown to have suppressive effects on pituitary TSH secretion in euthyroid individuals and patients with mild thyroid hormone resistance. We treated a 3-year-old boy with D-T4 who was homozygous for a T3 receptor d... |
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Treatment of pituitary resistance to thyroid hormone (PRTH) in an 8-year-old boy.
Acta Paediatr. 85(3) , 387-90, (1996) We report on an 8-year-old boy with pituitary resistance to thyroid hormone (PRTH) having a cysteine for arginine substitution at codon 320 in the TR-beta gene who was presented because of thyrotoxicosis. Due to its suppressive effect on the pituitary thyrotr... |
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A novel resistance to thyroid hormone associated with a new mutation (T329N) in the thyroid hormone receptor beta gene.
Thyroid 9(2) , 165-71, (1999) Resistance to thyroid hormone (RTH) is a syndrome of elevated serum thyroxine, inappropriately "normal" serum thyrotropin (TSH) and reduced thyroid hormone responsiveness associated with point mutations in the thyroid hormone receptor-beta (TRbeta) gene. We d... |
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Effect of L-thyroxine (LT4) and D-thyroxine (DT4) on cardiac function and high-energy phosphate metabolism: a 31P NMR study.
Magn. Reson. Med. 18(1) , 237-43, (1991) 31P NMR spectroscopy was used to monitor the cardiac energy metabolism in hypothyroid rat hearts. Differential alterations in phosphocreatine and inorganic phosphate levels were observed upon treatment of hypothyroid animals with DT4 and LT4, while both agent... |
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Steinernema feltiae (= Neoaplectana carpocapsae): effect of sterols and hypolipidemic agents on development.
Exp. Parasitol. 67(2) , 257-67, (1988) The structure and concentration of sterol in a lipid-defined artificial medium affected the development of the entomogenous nematode, Steinernema feltiae (= Neoaplectana carpocapsae). The nematode grew normally in vitro when the medium was supplemented with d... |
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Acute and chronic effects of dextro-thyroxine on pituitary thyroid axis and on reverse triiodothyronine production in euthyroid subjects.
J. Endocrinol. Invest. 10(1) , 73-7, (1987) Serum levels of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and TSH were measured in euthyroid subjects after a single dose of 4 mg D-thyroxine (DT4) or of 0.25 mg L-thyroxine (LT4). The same parameters and TSH response to TRH were a... |
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Effects of thyroxine and its related compounds on cerebral GABA receptors: inhibitory action on benzodiazepine recognition site in GABAA receptor complex.
Neurochem. Int. 25(5) , 451-4, (1994) The effects of thyroxine and its related derivatives on gamma-aminobutyric acid (GABA) receptors in the rat brain were examined. D-Thyroxine strongly inhibited [3H]flunitrazepam binding to benzodiazepine receptor in crude synaptic membrane from the rat brain.... |
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Purified D-thyroxine in athyreotic patients.
Lancet 341(8858) , 1477, (1993)
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