Scopolamine
Scopolamine structure
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Common Name | Scopolamine | ||
|---|---|---|---|---|
| CAS Number | 51-34-3 | Molecular Weight | 303.353 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 460.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C17H21NO4 | Melting Point | 59ºC | |
| MSDS | N/A | Flash Point | 232.2±28.7 °C | |
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Evidence for encoding versus retrieval scheduling in the hippocampus by theta phase and acetylcholine.
J. Neurosci. 33(20) , 8689-704, (2013) The formation of new memories requires new information to be encoded in the face of proactive interference from the past. Two solutions have been proposed for hippocampal region CA1: (1) acetylcholine, released in novelty, selectively suppresses excitatory pr... |
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[Effect of acteoside on learning and memory impairment induced by scopolamine in mice].
Zhongguo Zhong Yao Za Zhi 37(19) , 2956-9, (2012) To study on the effect of acteoside on learning and memory of dementia mice.Mice were orally administered with acteoside for 10 days. Scopolamine was used to establish the acquired learning disability in mice. Their learning and memory were detected with a be... |
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M1 and m2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine.
J. Pharmacol. Exp. Ther. 351(2) , 448-56, (2014) Scopolamine produces rapid and significant symptom improvement in patients with depression, and most notably in patients who do not respond to current antidepressant treatments. Scopolamine is a nonselective muscarinic acetylcholine receptor antagonist, and i... |
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[Simultaneous determination of scopolamine hydrobromide, atropine sulfate, ephedrine hydrochloride and pseudoephedrine hydrochloride in Zhichuanling oral liquid with HPLC].
Zhongguo Zhong Yao Za Zhi 38(19) , 3291-4, (2013) To establish an HPLC method for determining the contents of scopolamine hydrobromide, atropine sulfate, ephedrine hydrochloride and pseudoephedrine hydrochloride in Zhichuanling oral liquid.Agela Durashell RP-C18 (4. 6 mm x250 mm, 5 microm) was adopted, with ... |
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[Scopolamine and hyoscyamine synthesis in hair roots culture of Datura metel].
Zhongguo Zhong Yao Za Zhi 37(21) , 3223-8, (2012) To establish the hair roots culture system of Datura metel and study the hair roots growth and biosynthesis of scopolamine and hyoscyamine in hair roots culturing system.Direct degermed cotyledon of wild D. metel was infected by Agrobacterium tumefaciens stra... |
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Acute effects of a low-dose atropine/scopolamine mixture as a food contaminant in human volunteers.
J. Appl. Toxicol. 33(9) , 980-90, (2013) To verify the assumptions in our previous risk assessment of an atropine/scopolamine mixture in buckwheat flour, we performed a randomized, double-blind, placebo-controlled cross-over study in 20 healthy, adult volunteers. The volunteers ingested a traditiona... |
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Monitoring keratitis resolution with optical coherence tomography.
Optom. Vis. Sci. 91(4 Suppl 1) , S40-5, (2014) Biomicroscopy is generally used, sometimes in conjunction with photography or ultrasound pachymetry, to monitor conditions involving stromal keratitis and edema. Spectral-domain optical coherence tomography (SD-OCT), a technology typically used to examine the... |
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Performance of conventional pigs and Göttingen miniature pigs in a spatial holeboard task: effects of the putative muscarinic cognition impairer Biperiden.
Behav. Brain Funct. 9 , 4, (2013) The pig is emerging as a model species that bridges the gap between rodents and humans in research. In particular, the miniature pig (referred to hereafter as the minipig) is increasingly being used as non-rodent species in pharmacological and toxicological s... |
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An atypical pattern of accumulation of scopolamine and other tropane alkaloids and expression of alkaloid pathway genes in Hyoscyamus senecionis.
Plant Physiol. Biochem. 70 , 188-94, (2013) A cDNA encoding hyoscyamine 6β-hydroxylase (H6H, EC 1.14.11.11), a bifunctional enzyme catalyzing the last two steps in the scopolamine biosynthetic pathway, was isolated from Hyoscyamus senecionis, a medicinal plant endemic to the Iranian plateau. Expression... |
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The synthesis and evaluation of novel hydroxyl substituted chalcone analogs with in vitro anti-free radicals pharmacological activity and in vivo anti-oxidation activity in a free radical-injury Alzheimer's model.
Molecules 18(2) , 1693-703, (2013) Alzheimer's disease (AD) pathogenesis involves an imbalance between free radical formation and destruction. In order to obtain a novel preclinical anti-AD drug candidate, we synthesized a series of novel hydroxyl chalcone analogs which possessed anti-free rad... |