22(R)-HYDROXYCHOLESTEROL
22(R)-HYDROXYCHOLESTEROL structure
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Common Name | 22(R)-HYDROXYCHOLESTEROL | ||
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| CAS Number | 22348-64-7 | Molecular Weight | 402.65300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H46O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Tumor necrosis factor alpha may act as an intraovarian mediator of luteinizing hormone-induced oocyte maturation in trout.
Biol. Reprod. 86(1) , 1-12, (2012) In fish, like in other vertebrates, luteinizing hormone (Lh) is an essential hormone for the completion of oocyte maturation. In salmonid fish (i.e., salmon and trout), oocyte maturation is induced by Lh through its stimulation of the production of the matura... |
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CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.
Mol. Pharmacol. 87(5) , 878-89, (2015) Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that enhance the detoxification and elimination of xenobiotics and endobiotics by modulating the expression of genes encoding drug-metabolizing enzymes and transporter... |
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Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc.
Chem. Biol. Interact. 199(3) , 185-91, (2012) Cisplatin (Cs) is a chemotherapeutic agent able to generate reactive oxygen species (ROS) which are linked to several side effects of the drug. Even when it is known that Cs produces Leydig cell dysfunction, it is unknown whether this particular side effect i... |
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A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models.
Mol. Cell. Endocrinol. 366(1) , 31-7, (2013) The mineralocorticoid aldosterone plays an important role in regulating blood pressure, with excess causing hypertension and exacerbating cardiovascular disease. Previous studies have indicated a role for both phospholipase D (PLD) and protein kinase D (PKD) ... |
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Induction of DKK1 by ox-LDL negatively regulates intracellular lipid accumulation in macrophages.
FEBS Lett. 589(1) , 52-8, (2015) Dickkopf1 (DKK1), a canonical Wnt/β-catenin pathway antagonist, is closely associated with cardiovascular disease and adipogenesis. We performed an in vitro study to determine whether oxidized low-density lipoprotein (ox-LDL) increased the expression of DKK1 ... |
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Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors.
Placenta 32(2) , 183-91, (2011) Oxygenated cholesterol metabolites known as oxysterols display potent biological activities ranging from regulation of lipid homeostasis to cytotoxicity. Oxysterols have previously been shown to inhibit the invasion of first trimester trophoblasts, an effect ... |
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Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties.
J. Neuroendocrinol. 24(1) , 93-101, (2012) The overall ability of the brain to synthesise neuroactive steroids led us to the identification of compounds that would reproduce aspects of neurosteroid pharmacology. The rate-determining step in neurosteroid biosynthesis is the import of the substrate chol... |
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The human placenta expresses CYP17 and generates androgens de novo.
J. Clin. Endocrinol. Metab. 96(5) , 1385-92, (2011) The human placenta is believed to have insignificant CYP17 expression, rendering it dependent on the maternal and fetal compartments for the necessary androgenic precursors to yield the high levels of estrogens seen in pregnancy.The aim of the study was to an... |
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Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture.
J. Neurosci. Res. 87(11) , 2498-508, (2009) We determined the molecular mechanisms underlying apolipoprotein E (ApoE)-isoform-dependent lipid efflux from neurons and ApoE-deficient astrocytes in culture. The ability of ApoE3 to induce lipid efflux was 2.5- to 3.9-fold greater than ApoE4. To explore the... |
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Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes.
Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 160(2) , 125-36, (2011) The liver X receptor (LXR) has recently been described in salmonids. In mammals, this receptor is already known as a transcriptional factor that regulates diverse aspects of cholesterol, fatty acid and carbohydrate metabolism in various tissues, including mus... |