Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 22(R)-HYDROXYCHOLESTEROL
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22348-64-7

22348-64-7 structure

Name: 22(R)-HYDROXYCHOLESTEROL
Chemical Name: (22S)-22-hydroxycholesterol
CAS Number: 22348-64-7
Molecular Formula: C₂₇H₄₆O₂
Molecular Weight: 402.65300
Catalog: Research Areas Inflammation/Immunology
Create Date: 2019-01-01 14:05:53
Modify Date: 2024-01-16 16:50:46
Cholest-5-ene-3ß,22(S)-diol ((22S)-Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3ß,22(S)-diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models[1][2].

Name	(22S)-22-hydroxycholesterol
Synonyms	22S-hydroxycholesterol 22(R)-HYDROXYCHOLESTEROL beta2-Solamargine 22(S)-Hydroxycholesterol

Description	Cholest-5-ene-3ß,22(S)-diol ((22S)-Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3ß,22(S)-diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Cholest-5-ene-3ß,22(S)-diol (10 μg/mL, 20 μg/mL; 24 h) 对 U937 细胞磷脂酰丝氨酸外化、线粒体跨膜电位、细胞对碘化丙啶的通透性和细胞核形态变化无影响[1]。
In Vivo	Cholest-5-ene-3ß,22(S)-diol (30 mg/kg; 口服; 在加饮食中，共处理 3 周) 减少体重增加，消除高脂饮食引起的血清中三酰甘油 (TAG) 水平的增加[2]。在大鼠中的药代动力学分析[2] Route Dose (mg/kg) Cmax (ng/mL) Tmax (h) AUCt (ng·h/mL) AUC (ng·h/mL) T1/2 (h) Extent of tritium exchange (%) i.v. 50 22.4 0.08 174 195 8.1 2.8 p.o. 50 7.5 4 95.2 104 6.4 1.2 Animal Model: Male rats injected with Pentobarbital (20 mg, 50 mg/mL; i.p.)[2] Dosage: 30 mg/kg/day Administration: Oral gavage; 3 weeks consecutively Result: Decreased body weight gain significantly after 1 week treatment. Increased gene expression of Ucp3 and Cpt2 in liver and skeletal muscle, and increased protein level of Ucp3 in skeletal muscle after 3 weeks treatment.
References	[1]. Lemaire-Ewing S, et al. Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. Cell Biol Toxicol. 2005 Mar;21(2):97-114. [2]. Tranheim Kase E, et al. Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. Lipids. 2012 May;47(5):483-93.

Molecular Formula	C₂₇H₄₆O₂
Molecular Weight	402.65300
Exact Mass	402.35000
PSA	40.46000
LogP	6.35950

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