Leptomycin A
Leptomycin A structure
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Common Name | Leptomycin A | ||
|---|---|---|---|---|
| CAS Number | 87081-36-5 | Molecular Weight | 526.70400 | |
| Density | 1.079g/cm3 | Boiling Point | 717.7ºC at 760 mmHg | |
| Molecular Formula | C32H46O6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 224.2ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function.
Cell. Mol. Life Sci. 68 , 847-62, (2011) The mitogen-activated protein kinase-activated protein kinase-5 (MK5) resides predominantly in the nucleus of resting cells, but p38(MAPK), extracellular signal-regulated kinases-3 and -4 (ERK3 and ERK4), and protein kinase A (PKA) induce nucleocytoplasmic re... |
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Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization.
J. Antibiot. 36(6) , 639-45, (1983) A strain of Streptomyces was found to produce new antifungal antibiotics. The active compounds were purified and separated into two substances named leptomycin A and B by high performance liquid chromatography. The molecular formulae of leptomycins A and B ar... |
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Leptomycins A and B, new antifungal antibiotics. II. Structure elucidation.
J. Antibiot. 36(6) , 646-50, (1983) The structures of new antifungal antibiotics, leptomycins A and B produced by Streptomyces sp. ATS1287 were determined as described below (Fig. 1) on the basis of their spectral and chemical character. Leptomycins have unique structures which belong to the un... |
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Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST).
J. Biol. Chem. 277(14) , 12351-8, (2002) Mammalian STE20-like kinase (MST) is a member of the yeast STE20-related kinase family and proteolytically activated by caspase during apoptosis. However, its other cellular functions are not known, including its activation mechanism, substrate(s), and subcel... |
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[Leptomycin: a specific inhibitor of protein nuclear export].
Tanpakushitsu Kakusan Koso. 44(9) , 1379-88, (1999)
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Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation.
Mol. Cell. Biol. 22(16) , 5835-45, (2002) Estrogen receptors are phosphoproteins which can be activated by ligands, kinase activators, or phosphatase inhibitors. Our previous study showed that p38 mitogen-activated protein kinase was involved in estrogen receptor activation by estrogens and MEKK1. He... |
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Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin.
Proc. Natl. Acad. Sci. U. S. A. 101(9) , 2882-7, (2004) Wnt signaling regulates many aspects of development by increasing the signaling activity of beta-catenin. Axin is a negative regulator of the Wnt signaling pathway, and it is responsible for the formation of the beta-catenin degradation complex. Genetic studi... |
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ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase.
Biochim. Biophys. Acta 1803(2) , 234-45, (2010) Interleukin-6 (IL6) signals are mediated by classic and trans-signaling. In classic signaling, IL6 first binds to the membrane bound Interleukin-6 Receptor (IL6R) whereas in trans-signaling, IL6 acts via a soluble form of the IL6R. Trans-signaling via the sol... |
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Novel microbial metabolites of the phoslactomycins family induce production of colony-stimulating factors by bone marrow stromal cells. I. Taxonomy, fermentation and biological properties.
J. Antibiot. 46(10) , 1503-11, (1993) Three metabolites were isolated from the culture broth of an actinomycete strain identified as Streptomyces platensis SANK 60191, that induce the production of colony-stimulating factors (CSFs) by stromal cell line KM-102 at ED50 concentrations from 40 to 200... |
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Total synthesis of callystatin a by titanium-mediated reductive alkyne-alkyne cross-coupling.
Angew. Chem. Int. Ed. Engl. 47(41) , 7837-40, (2008)
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