E-64
E-64 structure
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Common Name | E-64 | ||
|---|---|---|---|---|
| CAS Number | 66701-25-5 | Molecular Weight | 357.405 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C15H27N5O5 | Melting Point | 182ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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Low concentrations of Bisphenol A and para-Nonylphenol affect extravillous pathway of human trophoblast cells.
Mol. Cell. Endocrinol. 412 , 56-64, (2015) Bisphenol A (BPA) and para-Nonylphenol (p-NP) are chemicals of industrial origin which may influence human reproductive health. The effects of these substances in the prenatal life is an important topic that is receiving greater attention in the developed cou... |
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The role of matrix metalloproteinases and cysteine-cathepsins on the progression of dentine erosion.
Arch. Oral Biol. 60 , 1340-5, (2015) To evaluate in vitro the effect of the inhibition of endogenous dentinal enzymes (matrix metalloproteinases-MMPs and cysteine cathepsins-CCs) on dentine erosion.Dentine blocks (4mm×4mm×2mm) from sound human teeth were randomly divided into 7 groups (n=17) acc... |
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Indomethacin inhibits activation of endothelial nitric oxide synthase in the rat kidney: possible role of this effect in the pathogenesis of indomethacin-induced renal damage.
Chem. Biol. Interact. 221 , 77-87, (2014) The clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with adverse effects in the kidney. Indomethacin, an NSAID that has been shown to induce oxidative stress in the kidney, was used to study the pathogenesis of renal damage ... |
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Identification and characterization of a cell division-regulating kinase AKB1 (associated kinase of Trypanosoma brucei 14-3-3) through proteomics study of the Tb14-3-3 binding proteins.
J. Biochem. 158 , 49-60, (2015) We used a proteomics approach to identify the binding partners of Trypanosoma brucei 14-3-3 (Tb14-3-3) which led to the identification of a novel kinase, AKB1. The binding between these two proteins was mediated by an amphipathic groove structure in Tb14-3-3 ... |
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Amyloid precursor protein mediated changes in intestinal epithelial phenotype in vitro.
PLoS ONE 10(3) , e0119534, (2015) Although APP and its proteolytic metabolites have been well examined in the central nervous system, there remains limited information of their functions outside of the brain. For example, amyloid precursor protein (APP) and amyloid beta (Aβ) immunoreactivity ... |
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Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors.
PLoS Negl. Trop. Dis. 9 , e0003916, (2015) A series of compounds based on the dipeptidyl nitrile scaffold were synthesized and assayed for their inhibitory activity against the T. cruzi cysteine protease cruzain. Structure activity relationships (SARs) were established using three, eleven and twelve v... |
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Corneal angiogenesis modulation by cysteine cathepsins: In vitro and in vivo studies.
Exp. Eye Res. 134 , 39-46, (2015) Corneal avascularization is essential for normal vision. Several antiangiogenic factors were identified in cornea such as endostatin and angiostatin. Cathepsin V, which is highly expressed in the cornea, can hydrolyze human plasminogen to release angiostatin ... |
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Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling.
Nat. Commun. 5 , 5409, (2014) Small ubiquitin-related modifiers (SUMO) are evolutionarily conserved ubiquitin-like proteins that regulate several cellular processes including cell cycle progression, intracellular trafficking, protein degradation and apoptosis. Despite the importance of pr... |
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Intracellular MMP-2 activity in skeletal muscle is associated with type II fibers.
J. Cell Physiol. 230(1) , 160-9, (2015) Matrix metalloproteinase 2 (MMP-2) is a proteolytic enzyme implicated in motility, differentiation, and regeneration of skeletal muscle fibers through processing of extracellular substrates. Although MMP-2 has been found to be localized intracellularly in car... |
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STAT3 regulates steady-state expression of synaptopodin in cultured mouse podocytes.
Mol. Pharmacol. 87(2) , 231-9, (2014) The transcription factor signal transducer and activator of transcription-3 (STAT3) is activated by proinflammatory cytokines and circulating factors in many cell types. Synaptopodin (Synpo) is a cytoskeleton regulatory protein expressed in podocyte foot proc... |