Doxycycline hyclate
Doxycycline hyclate structure
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Common Name | Doxycycline hyclate | ||
|---|---|---|---|---|
| CAS Number | 24390-14-5 | Molecular Weight | 512.94 | |
| Density | N/A | Boiling Point | 685.2ºC at 760 mmHg | |
| Molecular Formula | C22H24N2O8.1/2C2H6O.ClH.1/2H2O | Melting Point | 206-209?C (dec.) | |
| MSDS | Chinese USA | Flash Point | 368.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Phospho-tyrosine dependent protein-protein interaction network.
Mol. Syst. Biol. 11(3) , 794, (2015) Post-translational protein modifications, such as tyrosine phosphorylation, regulate protein-protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an established yeast two-hybrid system employing human protein kinases... |
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Antibacterial effect of doxycycline-coated dental abutment surfaces.
Biomed. Mater. 10 , 055003, (2015) Biofilm formation on dental abutment may lead to peri-implant mucositis and subsequent peri-implantitis. These cases are clinically treated with antibiotics such as doxycycline (Doxy). Here we used an electrochemical method of cathodic polarization to coat Do... |
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[Familial amyloid polyneuropathies: therapeutic issues].
Bull. Acad. Natl. Med. 196(7) , 1333-45; discussion 1345-7, (2012) Patients with familial amyloidpolyneuropathies (FAP) require multidisciplinary neurologic and cardiologic management, including specific treatments to control the progression of systemic amyloidogenesis, symptomatic treatment of peripheral and autonomic neuro... |
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Transcriptional profiling of cells sorted by RNA abundance.
Nature Methods 11(5) , 549-51, (2014) We have developed a quantitative technique for sorting cells on the basis of endogenous RNA abundance, with a molecular resolution of 10-20 transcripts. We demonstrate efficient and unbiased RNA extraction from transcriptionally sorted cells and report a high... |
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Effect of irrigation with Tetraclean on bacterial leakage of obturated root canals.
N. Y. State Dent. J. 80(3) , 39-43, (2014) The purpose of the study presented here was to evaluate the effect of Tetraclean, Hypoclean, Chlor-XTRA, 2% chlorhexidine and 6% sodium hypochlorite/17% EDTA as a final irrigant on bacterial leakage of the root canal. One hundred and fifty-five extracted huma... |
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Host and viral determinants of Mx2 antiretroviral activity.
J. Virol. 88(14) , 7738-52, (2014) Myxovirus resistance 2 (Mx2/MxB) has recently been uncovered as an effector of the anti-HIV-1 activity of type I interferons (IFNs) that inhibits HIV-1 at an early stage postinfection, after reverse transcription but prior to proviral integration into host DN... |
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Emerging therapies in rosacea.
J. Am. Acad. Dermatol. 69(6 Suppl 1) , S57-65, (2013) Rosacea is a common skin disorder with multiple symptoms. The emergence of research that furthers understanding of pathophysiological mechanisms has created new targets for disease treatment. Specifically, there is a need for new treatments that address the v... |
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A Novel Loading Method for Doxycycline Liposomes for Intracellular Drug Delivery: Characterization of In Vitro and In Vivo Release Kinetics and Efficacy in a J774A.1 Cell Line Model of Mycobacterium smegmatis Infection.
Drug Metab. Dispos. 43 , 1236-45, (2015) Doxycycline (doxy) is used in treating intracellular and extracellular infections. Liposomal (LE) antibiotics allow low-frequency dosing and extended efficacy compared with standard (STD) formulations. We developed a novel sulfuric acid-loading method for dox... |
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Synergistic effect of fluconazole and doxycycline against Candida albicans biofilms resulting from calcium fluctuation and downregulation of fluconazole-inducible efflux pump gene overexpression.
J. Med. Microbiol. 63(Pt 7) , 956-61, (2014) Candida albicans biofilms are intrinsically resistant to antimicrobial agents. Previous work demonstrated that the antifungal activity of fluconazole against C. albicans biofilms is notably enhanced by doxycycline. In order to explore the synergistic mechanis... |
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Occurrence of veterinary antibiotics and progesterone in broiler manure and agricultural soil in Malaysia.
Sci. Total Environ. 488-489 , 261-7, (2014) Repeated applications of animal manure as fertilizer are normal agricultural practices that may release veterinary antibiotics and hormones into the environment from treated animals. Broiler manure samples and their respective manure-amended agricultural soil... |