SB-366791
SB-366791 structure
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Common Name | SB-366791 | ||
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| CAS Number | 472981-92-3 | Molecular Weight | 287.741 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 494.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H14ClNO2 | Melting Point | 169 °C | |
| MSDS | USA | Flash Point | 252.7±28.7 °C | |
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Involvement of TRPV1 and TRPA1 in incisional intraoral and extraoral pain.
J. Dent. Res. 94(3) , 446-54, (2015) Thermal and mechanical hypersensitivity in the injured region is a common complication. Although it is well known clinically that thermal and mechanical sensitivity of the oral mucosa is different from that of the skin, the mechanisms underlying injured pain ... |
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Supraspinal TRPV1 modulates the emotional expression of abdominal pain.
Pain 155(10) , 2153-60, (2014) The transient receptor potential vanilloid receptor type-1 (TRPV1) is critically involved in peripheral nociceptive processes of somatic and visceral pain. However, the role of the capsaicin receptor in the brain regarding visceral pain remains elusive. Here,... |
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Acid solution is a suitable medium for introducing QX-314 into nociceptors through TRPV1 channels to produce sensory-specific analgesic effects.
PLoS ONE 6(12) , e29395, (2011) Previous studies have demonstrated that QX-314, an intracellular sodium channel blocker, can enter into nociceptors through capsaicin-activated TRPV1 or permeation of the membrane by chemical enhancers to produce a sensory-selective blockade. However, the obv... |
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Anticonvulsant effects of N-arachidonoyl-serotonin, a dual fatty acid amide hydrolase enzyme and transient receptor potential vanilloid type-1 (TRPV1) channel blocker, on experimental seizures: the roles of cannabinoid CB1 receptors and TRPV1 channels.
Basic Clin Pharmacol Toxicol. 115(4) , 330-4, (2014) Selective blockade of anandamide hydrolysis, through the inhibition of the FAAH enzyme, has anticonvulsant effects, which are mediated by CB1 receptors. Anandamide, however, also activates TRPV1 channels, generally with an opposite outcome on neuronal modulat... |