SB-366791
Modify Date: 2024-01-02 22:11:47
SB-366791 structure
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Common Name | SB-366791 | ||
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| CAS Number | 472981-92-3 | Molecular Weight | 287.741 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 494.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H14ClNO2 | Melting Point | 169 °C | |
| MSDS | USA | Flash Point | 252.7±28.7 °C | |
Use of SB-366791SB-366791 is a potent , competitive and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7±1.2 nMtarget: VR1/TRPV1IC 50: 5.7±1.2 nM [1] SB-366791 produced a concentration-dependent inhibition of the response to capsaicin with an apparent pKb of 7.74±0.08. Schild analysis indicated a competitive mechanism of action with a pA2 of 7.71.[1] SB-366791 showed a concentration-dependent potentiation of pH 5-induced 45Ca2+uptake in CHO cells expressing rat TRPV1 but not in untransfected cells[2] |
| Name | (E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide |
|---|---|
| Synonym | More Synonyms |
| Description | SB-366791 is a potent , competitive and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7±1.2 nMtarget: VR1/TRPV1IC 50: 5.7±1.2 nM [1] SB-366791 produced a concentration-dependent inhibition of the response to capsaicin with an apparent pKb of 7.74±0.08. Schild analysis indicated a competitive mechanism of action with a pA2 of 7.71.[1] SB-366791 showed a concentration-dependent potentiation of pH 5-induced 45Ca2+uptake in CHO cells expressing rat TRPV1 but not in untransfected cells[2] |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 494.2±45.0 °C at 760 mmHg |
| Melting Point | 169 °C |
| Molecular Formula | C16H14ClNO2 |
| Molecular Weight | 287.741 |
| Flash Point | 252.7±28.7 °C |
| Exact Mass | 287.071320 |
| PSA | 38.33000 |
| LogP | 4.52 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.650 |
| Storage condition | -20℃ |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Involvement of TRPV1 and TRPA1 in incisional intraoral and extraoral pain.
J. Dent. Res. 94(3) , 446-54, (2015) Thermal and mechanical hypersensitivity in the injured region is a common complication. Although it is well known clinically that thermal and mechanical sensitivity of the oral mucosa is different fro... |
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Supraspinal TRPV1 modulates the emotional expression of abdominal pain.
Pain 155(10) , 2153-60, (2014) The transient receptor potential vanilloid receptor type-1 (TRPV1) is critically involved in peripheral nociceptive processes of somatic and visceral pain. However, the role of the capsaicin receptor ... |
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Acid solution is a suitable medium for introducing QX-314 into nociceptors through TRPV1 channels to produce sensory-specific analgesic effects.
PLoS ONE 6(12) , e29395, (2011) Previous studies have demonstrated that QX-314, an intracellular sodium channel blocker, can enter into nociceptors through capsaicin-activated TRPV1 or permeation of the membrane by chemical enhancer... |
| 2-Propenamide, 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-, (2E)- |
| N-(3-Methoxyphenyl)-4-chlorocinnamide |
| (2E)-3-(4-Chlorophenyl)-N-(3-methoxyphenyl)acrylamide |
| SB-366791 |