Zofenopril calcium
Zofenopril calcium structure
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Common Name | Zofenopril calcium | ||
|---|---|---|---|---|
| CAS Number | 81938-43-4 | Molecular Weight | 448.58 | |
| Density | 1.34 g/cm3 | Boiling Point | 646.3ºC at 760 mmHg | |
| Molecular Formula | C22H22Ca0.5NO4S2 | Melting Point | >250ºC | |
| MSDS | Chinese USA | Flash Point | 344.7ºC | |
| Symbol |
GHS09 |
Signal Word | Warning | |
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Zofenopril plus hydrochlorothiazide fixed combination in the treatment of hypertension and associated clinical conditions.
Cardiovasc. Ther. 27(4) , 275-88, (2009) Zofenopril, is a highly lipophilic ACE inhibitor, characterized by long-lasting tissue penetration and sustained cardiac ACE inhibition, indicated for the treatment of hypertension and myocardial infarction. Comparative studies with different antihypertensive... |
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Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of zofenopril and its active metabolite zofenoprilat in human plasma.
J. Pharm. Biomed. Anal. 55(3) , 527-32, (2011) A novel, sensitive and rapid liquid chromatographic-electrospray ionization mass spectrometric method was developed and validated for the determination of zofenopril and its active metabolite zofenoprilat in human plasma. The method was based on a single extr... |
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Effects of zofenopril and ramipril on cough reflex responses in anesthetized and awake rabbits.
J. Cardiovasc. Pharmacol. Ther. 15(4) , 384-92, (2010) Cough is the most common symptom reported by patients in a primary care setting and is one of the most frequent secondary effects recorded during treatment with angiotensin-converting enzyme (ACE) inhibitors. The aim of the current study was to analyze potent... |
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Aliskiren, a renin inhibitor, downregulates TNF-α-induced tissue factor expression in HUVECS.
J. Renin Angiotensin Aldosterone Syst. 11(4) , 243-7, (2010) Angiotensin (Ang)II, the effector arm of the locally active renin-angiotensin system (RAS), modulates Tissue Factor (TF), the principal initiator of blood coagulation and a key promoter of atherothrombotic events. Consistent with that knowledge, previous data... |
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Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2.
Naunyn Schmiedebergs Arch. Pharmacol. 382(5-6) , 455-61, (2010) Dry and persistent cough is one of the commonest side effects experienced by patients treated with angiotensin-converting enzyme (ACE) inhibitors for the therapy of hypertension and congestive heart failure. The present study investigated the effect of zofeno... |
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Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling.
J. Cardiovasc. Pharmacol. 54(5) , 456-63, (2009) Isolated rat hearts were perfused for 120 minutes in the presence or in the absence of 10 microM zofenoprilat, the active metabolite of zofenopril. At the end of perfusion, cardiac tissue was used to assay sarcoplasmic reticulum (SR) (45)Ca uptake and SR calc... |
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Protective effects of zofenopril on testicular torsion and detorsion injury in rats.
Urol. J. 8(4) , 313-9, (2011) To investigate the protective effect of zofenopril on torsion/detorsion-induced biochemical and histopathological changes in experimental testicular ischemia or reperfusion injury in rats.A total of 35 prepubertal male Wistar-Albino rats were divided into fiv... |
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Serum cholesterol levels on admission and survival in patients with acute myocardial infarction treated with zofenopril: a post hoc analysis of the Survival of Myocardial Infarction Long-term Evaluation trial.
Fundam. Clin. Pharmacol. 23(5) , 641-8, (2009) To evaluate the clinical efficacy of early angiotensin-converting enzyme (ACE) inhibition by zofenopril in patients with anterior myocardial infarction and normal or high plasma low density lipoprotein-cholesterolaemia. Post hoc analysis of the Survival of My... |
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Cardioprotective effects of zofenopril, enalapril and valsartan against ischaemia/reperfusion injury as well as doxorubicin cardiotoxicity.
Acta Cardiol. 67(1) , 87-96, (2012) The aim of this study is to compare possible protective effects of zofenopril, enalapril and valsartan against both ischaemia/reperfusion injury as well as acute doxorubicin cardiotoxicity. All three agents have never been compared in this setting before.Sixt... |
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Effect of acute and chronic zofenopril administration on cardiac gene expression.
Mol. Cell Biochem. 352(1-2) , 301-7, (2011) We investigated whether acute and chronic administration of zofenopril, an angiotensin converting enzyme inhibitor, may modulate the expression of genes which are involved in the pathophysiology of myocardial ischemia and heart failure. We used an acute and a... |