Guanabenz acetate
Guanabenz acetate structure
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Common Name | Guanabenz acetate | ||
|---|---|---|---|---|
| CAS Number | 23256-50-0 | Molecular Weight | 291.13400 | |
| Density | N/A | Boiling Point | 405.7ºC at 760 mmHg | |
| Molecular Formula | C10H12Cl2N4O2 | Melting Point | 227-229ºC (decomposition) | |
| MSDS | Chinese USA | Flash Point | 199.1ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration.
J. Clin. Invest. 123(12) , 5119-34, (2013) A systems pharmacological approach that capitalizes on the characterization of intracellular signaling networks can transform our understanding of human diseases and lead to therapy development. Here, we applied this strategy to identify pharmacological targe... |
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CD36 deletion improves recovery from spinal cord injury
Exp. Neurol. 256 , 25-38, (2014) CD36 is a pleiotropic receptor involved in several pathophysiological conditions, including cerebral ischemia, neurovascular dysfunction and atherosclerosis, and recent reports implicate its involvement in the endoplasmic reticulum stress response (ERSR). We ... |
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Hepatic, extrahepatic, microsomal, and mitochondrial activation of the N-hydroxylated prodrugs benzamidoxime, guanoxabenz, and Ro 48-3656 ([[1-[(2s)-2-[[4-[(hydroxyamino)iminomethyl]benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxy]-acetic acid).
Drug Metab. Dispos. 33(11) , 1740-7, (2005) In previous studies, it was shown that liver microsomes from rabbit, rat, pig, and human are involved in the reduction of N-hydroxylated amidines, guanidines, and amidinohydrazones of various drugs and model compounds (Drug Metab Rev 34: 565-579). One respons... |
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Guanabenz Treatment Accelerates Disease in a Mutant SOD1 Mouse Model of ALS.
PLoS ONE 10 , e0135570, (2015) Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons. The mechanisms leading to motor neuron degeneration in ALS are unclear. However, there is evidence for involvement of endoplasmic reticulum ... |
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Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii.
Antimicrob. Agents Chemother. 57(4) , 1815-22, (2013) Toxoplasma gondii is an obligate intracellular parasite that permanently infects warm-blooded vertebrates through its ability to convert into a latent tissue cyst form. The latent form (bradyzoite) can reinitiate a life-threatening acute infection if host imm... |
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Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy.
EMBO Mol. Med. 3 , 35-49, (2011) Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset syndrome characterized by progressive degeneration of specific muscles. OPMD is caused by extension of a polyalanine tract in poly(A) binding protein nuclear 1 (PABPN1). Insoluble nuclear inclusions ... |
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Modification of atrial natriuretic peptide system in cold-induced hypertensive rats.
Regul. Pept. 154(1-3) , 112-20, (2009) Cold exposure induces hypertension and cardiac hypertrophy via sympathetic activation. The sympathetic nervous system is fundamentally important for the regulation of cardiac atrial natriuretic peptide (ANP) secretion. The present study aimed to define change... |