Bisindolylmaleimide IV
Bisindolylmaleimide IV structure
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Common Name | Bisindolylmaleimide IV | ||
|---|---|---|---|---|
| CAS Number | 119139-23-0 | Molecular Weight | 327.336 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 690.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C20H13N3O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 371.2±31.5 °C | |
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Ca2+ influx through P2X1 receptors amplifies P2Y1 receptor-evoked Ca2+ signaling and ADP-evoked platelet aggregation.
Mol. Pharmacol. 86(3) , 243-51, (2014) Many cells express both P2X cation channels and P2Y G-protein-coupled receptors that are costimulated by nucleotides released during physiologic or pathophysiologic responses. For example, during hemostasis and thrombosis, ATP-gated P2X1 channels and ADP-stim... |
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High glucose-induced RhoA activation requires caveolae and PKCβ1-mediated ROS generation.
Am. J. Physiol. Renal Physiol. 302(1) , F159-72, (2012) Glomerular matrix accumulation is a hallmark of diabetic nephropathy. We previously showed that RhoA activation by high glucose in mesangial cells (MC) leads to matrix upregulation (Peng F, Wu D, Gao B, Ingram AJ, Zhang B, Chorneyko K, McKenzie R, Krepinsky J... |
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Entry of Newcastle Disease Virus into the host cell: role of acidic pH and endocytosis.
Biochim. Biophys. Acta 1838(1 Pt B) , 300-9, (2014) Most paramyxoviruses enter the cell by direct fusion of the viral envelope with the plasma membrane. Our previous studies have shown the colocalization of Newcastle Disease Virus (NDV) with the early endosome marker EEA1 and the inhibition of NDV fusion by th... |
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Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells.
J. Physiol. 588(Pt 14) , 2605-19, (2010) In vertebrate retina, melatonin regulates various physiological functions. In this work we investigated the mechanisms underlying melatonin-induced potentiation of glycine currents in rat retinal ganglion cells (RGCs). Immunofluorescence double labelling show... |
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Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells.
Prostate 70(10) , 1119-26, (2010) We have reported that human prostate cancer ARCaP(E) cells undertake epithelial to mesenchymal transition (EMT) when stimulated by certain soluble factors, and that EMT is regulated by surface receptor-elicited signaling pathways through protein phosphorylati... |
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Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation.
Mol. Endocrinol. 25(12) , 2144-56, (2011) We recently reported that IGF-II binding to the IGF-II/mannose-6-phosphate (M6P) receptor activates the ERK1/2 cascade by triggering sphingosine kinase 1 (SK1)-dependent transactivation of G protein-coupled sphingosine 1-phosphate (S1P) receptors. Here, we in... |
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PKC alpha phosphorylates cytosolic NF-kappaB/p65 and PKC delta delays nuclear translocation of NF-kappaB/p65 in U1242 glioblastoma cells.
Turk. Neurosurg. 20(3) , 277-85, (2010) Protein kinase-C (PKC) and NF-kappaB are involved in cell survival, proliferation, migration and radioresistance in glioblastoma multiforme (GBM). We sought to determine the interaction between PKC and NF-kappaB pathways.The activation of NF-kappaB by PKC alp... |
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Synthesis of N-methyl-bisindolylmaleimide amino acid methyl ester conjugates and cytotoxicity study.
Eur. J. Med. Chem. 45(9) , 4175-9, (2010) A novel series of N-methylbisindolylmaleimides derivatives bearing 2-acetamino acid moieties were synthesized. The cytotoxic activities of these compounds were tested in six tumor cell lines. The most potent compound 8d displayed cytotoxicity against six huma... |
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Protein kinase C mediates peroxynitrite toxicity to oligodendrocytes.
Mol. Cell. Neurosci. 48(1) , 62-71, (2011) Peroxynitrite has been suggested to be the potent oxidant causing toxicity to neurons and oligodendrocytes (OLs). Our previous studies have illustrated that intracellular zinc liberation contributes to peroxynitrite toxicity to mature OLs. In this study, we f... |
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Binding of BIS like and other ligands with the GSK-3β kinase: a combined docking and MM-PBSA study.
J. Mol. Model. 18(2) , 631-44, (2012) Binding of several bisindolylmaleimide (BIS) like (BIS-3, BIS-8 and UCN1) and other ligands (H89, SB203580 and Y27632) with the glycogen synthase kinase-3 (GSK-3β) has been studied using combined docking, molecular dynamics and Poisson-Boltzmann surface area ... |