European Journal of Medicinal Chemistry 2010-09-01

Synthesis of N-methyl-bisindolylmaleimide amino acid methyl ester conjugates and cytotoxicity study.

Ke Wang, Zhan-Zhu Liu

Index: Eur. J. Med. Chem. 45(9) , 4175-9, (2010)

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Abstract

A novel series of N-methylbisindolylmaleimides derivatives bearing 2-acetamino acid moieties were synthesized. The cytotoxic activities of these compounds were tested in six tumor cell lines. The most potent compound 8d displayed cytotoxicity against six human tumor cell lines in the micromolar range.2010 Elsevier Masson SAS. All rights reserved.