(r,s)-n-nitrosoanabasine

(r,s)-n-nitrosoanabasine Structure
(r,s)-n-nitrosoanabasine structure
Common Name (r,s)-n-nitrosoanabasine
CAS Number 1133-64-8 Molecular Weight 191.23000
Density 1.24g/cm3 Boiling Point 380.2ºC at 760mmHg
Molecular Formula C10H13N3O Melting Point N/A
MSDS N/A Flash Point 9℃
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger

Oral mucosal changes and nicotine disposition in users of Swedish smokeless tobacco products: a comparative study.

J. Oral. Pathol. Med. 23(4) , 161-7, (1994)

The purpose of this study was to investigate the uptake and metabolism of nicotine by smokeless (oral) tobacco users and to find out if the less pronounced clinical changes in the oral mucosa in users of portion-bag packed oral moist snuff (snus) compared wit...

N'-Nitrosoanabasine (NAB).

IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 37 , 225-31, (1985)

Immunotoxic effects of smokeless tobacco on the accessory cell function of rat oral epithelium.

Eur. J. Oral Sci. 105(1) , 45-51, (1997)

Smokeless tobacco (ST) is known to adversely effect the oral mucosa, but knowledge about the influence on immune defence is limited. Few studies have investigated the effect of ST on the local immune response. In the present study, we have assessed the effect...

Carcinogenic tobacco-specific nitrosamines are present at unusually high levels in the saliva of oral snuff users in Sudan.

Carcinogenesis 13(6) , 1001-5, (1992)

Exposure to tobacco-specific nitrosamines (TSNA) has been measured in the saliva of 12 users of Sudanese oral snuff (toombak). Using GC coupled to thermal energy analysis, levels of N'-nitrosonornicotine (NNN), N'-nitrosoanatabine (NAT), N'-nitrosoanabasine (...

Unusually high levels of carcinogenic tobacco-specific nitrosamines in Sudan snuff (toombak).

Carcinogenesis 12(6) , 1115-8, (1991)

The aim of these studies was to determine the levels of carcinogenic tobacco specific nitrosamines (TSNA) in Sudanese oral snuff (toombak) as recent retrospective epidemiological studies suggested an association between the use of toombak and subsequent devel...

Regiospecificity in the metabolism of the homologous cyclic nitrosamines, N'-nitrosonornicotine and N'-nitrosoanabasine.

Carcinogenesis 3(10) , 1195-9, (1982)

We compared the metabolism in the F-344 rat of the moderately potent esophageal carcinogen N'-nitrosonornicotine (NNN, 2'-(3-pyridyl)-N-nitrosopyrrolidine) and its weakly active homologue N'-nitrosoanabasine (NAB, 2'-(3-pyridyl)-N-nitrosopiperidine). Urine wa...

Analysis of tobacco-specific nitrosamines in Moldovan cigarette tobacco.

J. Agric. Food Chem. 50(10) , 2793-7, (2002)

Tobacco-specific nitrosamines (TSNA) are among the most important and abundant strongly carcinogenic agents in unburned tobacco. It has been established that 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces lung tumors in rodents independent of th...

The migration of tobacco-specific nitrosamines into the saliva of chewers of nicotine-containing chewing gum.

Food Chem. Toxicol. 28(9) , 619-22, (1990)

In many countries nicotine-containing chewing gum (Nicorette) is used to help to break the habit of smoking. Saliva was collected every 5 min from chewers of nicotine chewing gum and analysed for tobacco-specific nitrosamines. Detectable levels of tobacco-spe...

Smoke yields of tobacco-specific nitrosamines in relation to FTC tar level and cigarette manufacturer: analysis of the Massachusetts Benchmark Study.

Public Health Rep. 116(4) , 336-43, (2001)

This research assessed the relationship between the deliveries of carcinogenic tobacco-specific nitrosamines (TSNAs) and the Federal Trade Commission (FTC) "tar" ratings of US commercial cigarettes.Analysis of covariance (ANCOVA) was used to assess the explan...

Determination of tobacco-specific N-nitrosamines in urine of smokers and non-smokers.

Biomarkers 14(8) , 547-53, (2009)

Tobacco-specific N-nitrosamines (TSNA) include 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N'-nitrosonornicotine (NNN), N'-nitrosoanabasine (NAB) and N'-nitrosoanatabine (NAT) and are found in tobacco and tobacco smoke. TSNA are of interest for biom...