S-(2-Aminoethyl)-L-cysteine hydrochloride
S-(2-Aminoethyl)-L-cysteine hydrochloride structure
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Common Name | S-(2-Aminoethyl)-L-cysteine hydrochloride | ||
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| CAS Number | 4099-35-8 | Molecular Weight | 200.68700 | |
| Density | 1.289g/cm3 | Boiling Point | 341.1ºC at 760 mmHg | |
| Molecular Formula | C5H13ClN2O2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 160.1ºC | |
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Evidence for conformational movement and radical mechanism in the reaction of 4-thia-L-lysine with lysine 5,6-aminomutase.
J. Phys. Chem. B 113(36) , 12161-3, (2009) We demonstrate that the steady state reaction of lysine 5,6-aminomutase with substrate analogue 4-thia-l-lysine generates a radical intermediate, which accumulates in the enzyme to an electron paramagnetic resonance (EPR) detectable level. EPR line width narr... |
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Radical triplets and suicide inhibition in reactions of 4-thia-D- and 4-thia-L-lysine with lysine 5,6-aminomutase.
Biochemistry 48(34) , 8151-60, (2009) Lysine 5,6-aminomutase (5,6-LAM) catalyzes the interconversions of D- or L-lysine and the corresponding enantiomers of 2,5-diaminohexanoate, as well as the interconversion of L-beta-lysine and l-3,5-diaminohexanoate. The reactions of 5,6-LAM are 5'-deoxyadeno... |
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Inhibition of lysine 2,3-aminomutase by the alternative substrate 4-thialysine and characterization of the 4-thialysyl radical intermediate.
Arch. Biochem. Biophys. 387(2) , 281-8, (2001) Lysine 2,3-aminomutase catalyzes the interconversion of L-lysine and L-beta-lysine. 4-Thia-L-lysine (4-thialysine) is an alternative substrate for Lysine 2,3-aminomutase. The organic free radical that appears in the steady state of the reaction of 4-thialysin... |
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A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine [S-(2-aminoethyl)-L-cysteine].
Biochem. J. 384(Pt 1) , 129-37, (2004) The putative diamine N-acetyltransferase D2023.4 has been cloned from the model nematode Caenorhabditis elegans. The 483 bp open reading frame of the cDNA encodes a deduced polypeptide of 18.6 kDa. Accordingly, the recombinantly expressed His6-tagged protein ... |
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Stringent mating-type-regulated auxotrophy increases the accuracy of systematic genetic interaction screens with Saccharomyces cerevisiae mutant arrays.
Genetics 181(1) , 289-300, (2009) A genomic collection of haploid Saccharomyces cerevisiae deletion strains provides a unique resource for systematic analysis of gene interactions. Double-mutant haploid strains can be constructed by the synthetic genetic array (SGA) method, wherein a query mu... |
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Aminoethylation in model peptides reveals conditions for maximizing thiol specificity.
Arch. Biochem. Biophys. 443(1-2) , 1-10, (2005) Control of pH in aminoethylation reactions is critical for maintaining high selectivity towards cysteine modification. Measurement of aminoethylation rate constants by liquid chromatography mass spectrometry demonstrates reaction selectivity of cysteine>>amin... |
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Chemical-modification rescue assessed by mass spectrometry demonstrates that gamma-thia-lysine yields the same activity as lysine in aldolase.
Protein Sci. 11(7) , 1591-9, (2002) The role of active site residues in fructose 1,6-bisphosphate aldolase is investigated by chemical-modification rescue. An active-site mutation, K107C, is constructed in a background where the four solvent-accessible cysteine residues are converted to alanine... |
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Synthesis of 4-thia-[6-(13)C]lysine from [2- (13)C]glycine: access to site-directed isotopomers of 2-aminoethanol, 2-bromoethylamine and 4-thialysine.
Amino Acids 42(1) , 309-15, (2012) 4-Thialysine (S-(2-aminoethyl)-L: -cysteine) is an analog of lysine. It has been used as an alternative substrate for lysine in enzymatic reactions. Site-directed isotopomers are often needed for elucidation of mechanism of reactions. 4-Thialysine can be synt... |
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Non-antibiotic selection systems for soybean somatic embryos: the lysine analog aminoethyl-cysteine as a selection agent.
BMC Biotechnol. 9 , 94, (2009) In soybean somatic embryo transformation, the standard selection agent currently used is hygromycin. It may be preferable to avoid use of antibiotic resistance genes in foods. The objective of these experiments was to develop a selection system for producing ... |
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Selectivity of labeled bromoethylamine for protein alkylation.
J. Mol. Model. 18(9) , 4547-56, (2012) Alkylation of cysteine residues has been used extensively for characterization of proteins and their mode of action in biological systems, research endeavors that are at the core of proteomics. Treatment with a simple alkylating agent such as [2-(13)C] bromoe... |