1,3-Dicyclohexylurea
1,3-Dicyclohexylurea structure
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Common Name | 1,3-Dicyclohexylurea | ||
|---|---|---|---|---|
| CAS Number | 2387-23-7 | Molecular Weight | 224.34 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 364.3±25.0 °C at 760 mmHg | |
| Molecular Formula | C13H24N2O | Melting Point | 232-233 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 174.1±23.2 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment.
Nanoscale 7 , 12096-103, (2015) A multifunctional gold nanorod (AuNR) complex is described with potential utility for theranostic anticancer treatment. The AuNR was functionalized with cyclodextrin for encapsulation of doxorubicin, with folic acid for targeting, and with a photo-responsive ... |
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Synthesis, characterization and mechanistic-insight into the anti-proliferative potential of PLGA-gemcitabine conjugate.
Int. J. Pharm. 470(1-2) , 51-62, (2014) Gemcitabine, a nucleoside analogue, is used in the treatment of various solid tumors, however, its efficacy is limited by rapid metabolism by cytidine deaminase and fast kidney excretion. In this study, a polymeric conjugate of gemcitabine was prepared by cov... |
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Targeting liver cancer via ASGP receptor using 5-FU-loaded surface-modified PLGA nanoparticles.
J. Microencapsul. 31(5) , 479-87, (2014) Liver cancer is widespread liver malignancy in the world, for an estimated one million deaths annually.In present work, lactobionic acid conjugated PLGA nanoparticles (LDNPs) bearing 5-Fluorouracil (5-FU) were developed for targeted delivery to hepatocellular... |
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Reinvestigation of the reactions of carbodiimides with alkoxycarbonylamino acid symmetrical anhydrides. Isolation of two N-acylureas.
Int. J. Pept. Protein Res. 43 , 184, (1994) Alkoxycarbonylamino acid symmetrical anhydrides were allowed to react with N,N'-diisopropylcarbodiimide. The determination of the decrease in carbodiimide concentration indicated that the reaction was slow and proceeded indirectly. It is presumed that symmetr... |
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Thermal degradation of amorphous glibenclamide.
Eur. J. Pharm. Biopharm. 80(1) , 203-8, (2012) A glibenclamide polymorph published by Panagopoulou-Kaplani and Malamataris (2000) [1], obtained by sublimation of amorphous glibenclamide, was analysed. A new interpretation of the data is presented and experimentally confirmed by X-ray powder diffractometry... |
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Development of Ecom₅₀ and retention index models for nontargeted metabolomics: identification of 1,3-dicyclohexylurea in human serum by HPLC/mass spectrometry.
J. Chem. Inf. Model. 52(5) , 1222-37, (2012) The goal of many metabolomic studies is to identify the molecular structure of endogenous molecules that are differentially expressed among sampled or treatment groups. The identified compounds can then be used to gain an understanding of disease mechanisms. ... |
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Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids.
Circ. Res. 87(11) , 992-8, (2000) The cytochrome P450-derived epoxyeicosatrienoic acids (EETs) have potent effects on renal vascular reactivity and tubular sodium and water transport; however, the role of these eicosanoids in the pathogenesis of hypertension is controversial. The current stud... |
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Orally bioavailable potent soluble epoxide hydrolase inhibitors.
J. Med. Chem. 50 , 3825-40, (2007) A series of N,N'-disubstituted ureas having a conformationally restricted cis- or trans-1,4-cyclohexane alpha to the urea were prepared and tested as soluble epoxide hydrolase (sEH) inhibitors. This series of compounds showed low nanomolar to picomolar activi... |
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14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha.
Am. J. Physiol. Heart Circ. Physiol. 290(1) , H55-63, (2006) Epoxyeicosatrienoic acids (EETs), lipid mediators synthesized from arachidonic acid by cytochrome P-450 epoxygenases, are converted by soluble epoxide hydrolase (SEH) to the corresponding dihydroxyeicosatrienoic acids (DHETs). Originally considered as inactiv... |
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Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats.
Basic Clin Pharmacol Toxicol. 102(5) , 453-8, (2008) Cytochrome P450-derived epoxyeicosatrienoic acids (EET) are biologically active metabolites of arachidonic acid that have potent effects on renal vascular reactivity and tubular ion transport and have been implicated in the control of blood pressure. EETs are... |