Ro 22-3581
Ro 22-3581 structure
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Common Name | Ro 22-3581 | ||
|---|---|---|---|---|
| CAS Number | 10041-06-2 | Molecular Weight | 186.21000 | |
| Density | 1.13g/cm3 | Boiling Point | 360.9ºC at 760 mmHg | |
| Molecular Formula | C11H10N2O | Melting Point | 108-110 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 172.1ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Suppression of urinary albumin excretion in diabetic rats by 4'(imidazol-1-yl) acetophenone, a selective inhibitor of thromboxane synthesis.
J. Lab. Clin. Med. 116(4) , 469-78, (1990) Thromboxane contributes to the regulation of glomerular hemodynamics in experimental models of diabetes and has been implicated as mediator in some models of glomerular injury. In the present study we examined urinary albumin, protein, and thromboxane B2 (TXB... |
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Thromboxane and pulmonary hypertension following E. coli endotoxin infusion in sheep: effect of an imidazole derivative.
Prostaglandins 23(3) , 273-85, (1982) We assessed the effect of a specific thromboxane synthetase inhibitor (an imidazole derivative) on pulmonary hemodynamics and the concentrations of TxB2 (TxA2), 6-keto-PGF1 alpha (PGI2), and PGF2 in pulmonary lymph and transpulmonary blood samples following i... |
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Attenuation of the development of hypertension in spontaneously hypertensive rats by the thromboxane synthetase inhibitor, 4'-(imidazol-1-yl) acetophenone.
Prostaglandins 24(2) , 237-44, (1982) The compound 4'-(imidazol-1-yl) acetophenone was demonstrated to be a selective thromboxane (Tx) synthetase inhibitor in spontaneously hypertensive rats (SHR). Serum TxB2 concentrations (from clotted blood) were suppressed by 89.1% (p less than 0.001) and 41.... |
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Selective inhibition of thromboxane synthesis in glycerol-induced acute renal failure.
Am. J. Kidney Dis. 8(1) , 26-30, (1986) It has recently been postulated that thromboxane A2 may participate in the pathogenesis of acute myohemoglobinuric experimental acute renal failure. To investigate this further, the effect of selective inhibition of thromboxane synthesis on the course of glyc... |
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A pharmacotherapeutic approach to the regulation of hyperinsulinemia and obesity.
Int. J. Obes. 11 Suppl 3 , 43-51, (1987) A selective inhibitor of thromboxane synthase, Ro 22-3581 has been shown to be a useful tool for investigating the relationship between hyperinsulinemia and obesity. These studies have established that the pharmacologic normalization of the hyperinsulinemia a... |