2'-O-Succinyl-cAMP
2'-O-Succinyl-cAMP structure
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Common Name | 2'-O-Succinyl-cAMP | ||
|---|---|---|---|---|
| CAS Number | 36940-87-1 | Molecular Weight | 429.27900 | |
| Density | 2.16g/cm3 | Boiling Point | 781.3ºC at 760mmHg | |
| Molecular Formula | C14H16N5O9P | Melting Point | N/A | |
| MSDS | USA | Flash Point | 426.3ºC | |
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Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells.
Endocrinology 151 , 2151-2161, (2010) In the adrenal cortex, the biosynthesis of steroid hormones is controlled by the pituitary-derived hormone ACTH. The functions of ACTH are principally relayed by activating cAMP-dependent signaling pathways leading to the induction of genes encoding enzymes i... |
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Different role of cAMP dependent protein kinase and CaMKII in H3 receptor regulation of histamine synthesis and release
Neuroscience 164 , 1244-1251, (2009) Histamine H3 autoreceptors induce a negative feedback on histamine synthesis and release. While it is known that cAMP/cAMP dependent protein kinase (PKA) and Ca2+/CaMKII transduction pathways mediate H3 effects on histamine synthesis, the pathways regulating ... |
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A real-time fluorescent assay of the purified nitric oxide receptor, guanylyl cyclase.
Anal. Biochem. 402 , 129-136, (2010) Nitric oxide (NO) mediates intercellular signaling through activation of its receptor, soluble guanylyl cyclase (sGC), leading to elevation of intracellular guanosine 3',5'-cyclic monophosphate (cGMP) levels. Through this signal transduction pathway, NO regul... |
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Preparation of cyclic nucleotide antisera with thyroglobulin-cyclic nucleotide conjugates.
J. Cyclic Nucleotide Res. 6(6) , 461-8, (1980) Antisera to cyclic AMP and cyclic GMP were obtained by immunizing rabbits with antigens prepared by conjugating the 2'0-succinyl derivative of the cyclic nucleotides to thyroglobulin. The cyclic nucleotide-thyroglobulin conjugates were injected intradermally ... |
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Elucidation of the substrate specificity, kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum.
Biochim. Biophys. Acta 1794(4) , 642-54, (2009) Adenylosuccinate lyase (ASL) catalyzes two distinct but chemically similar reactions in purine biosynthesis. The first, exclusive to the de novo pathway involves the cleavage of 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) to 5-aminoimid... |
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Characterization of cell surface adenosine 3',5'-monophosphate-binding proteins in Y-1 mouse adrenal tumor cells.
Endocrinology 116(3) , 935-44, (1985) Adrenal cortical cells are known to export cAMP and have binding proteins and cAMP-dependent protein kinase activity associated with their plasma membranes. Because these properties suggest a function for extracellular cAMP, we have undertaken a search for sp... |