2'-O-Succinyl-cAMP

Modify Date: 2024-01-02 17:32:54

2'-O-Succinyl-cAMP Structure
2'-O-Succinyl-cAMP structure
Common Name 2'-O-Succinyl-cAMP
CAS Number 36940-87-1 Molecular Weight 429.27900
Density 2.16g/cm3 Boiling Point 781.3ºC at 760mmHg
Molecular Formula C14H16N5O9P Melting Point N/A
MSDS USA Flash Point 426.3ºC

 Use of 2'-O-Succinyl-cAMP


2'-O-Succinyl-cAMP is a cAMP analog that can be covalently coupled to acetylcholinesterase. 2'-O-Succinyl-cAMP conjugate has been used as tracers in a classical heterogeneous competitive enzyme immunoassay allowing the determination of cAMP[1][2].

 Names

Name 2'-o-monosuccinyladenosine 3':5'-cyclic monophosphate
Synonym More Synonyms

 2'-O-Succinyl-cAMP Biological Activity

Description 2'-O-Succinyl-cAMP is a cAMP analog that can be covalently coupled to acetylcholinesterase. 2'-O-Succinyl-cAMP conjugate has been used as tracers in a classical heterogeneous competitive enzyme immunoassay allowing the determination of cAMP[1][2].
Related Catalog
References

[1]. Pradelles P, et, al. Enzyme immunoassays of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate using acetylcholinesterase. Anal Chem. 1989 Mar 1;61(5):447-53.

[2]. Luttrell BM, et, al. Reaction coupling of chelation and antigen binding in the calcium ion-dependent antibody binding of cyclic AMP. J Biol Chem. 1991 Nov 15;266(32):21626-30.

 Chemical & Physical Properties

Density 2.16g/cm3
Boiling Point 781.3ºC at 760mmHg
Molecular Formula C14H16N5O9P
Molecular Weight 429.27900
Flash Point 426.3ºC
Exact Mass 429.06900
PSA 208.02000
LogP 0.17950
Index of Refraction 1.849

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles6

More Articles
Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells.

Endocrinology 151 , 2151-2161, (2010)

In the adrenal cortex, the biosynthesis of steroid hormones is controlled by the pituitary-derived hormone ACTH. The functions of ACTH are principally relayed by activating cAMP-dependent signaling pa...

Different role of cAMP dependent protein kinase and CaMKII in H3 receptor regulation of histamine synthesis and release

Neuroscience 164 , 1244-1251, (2009)

Histamine H3 autoreceptors induce a negative feedback on histamine synthesis and release. While it is known that cAMP/cAMP dependent protein kinase (PKA) and Ca2+/CaMKII transduction pathways mediate ...

A real-time fluorescent assay of the purified nitric oxide receptor, guanylyl cyclase.

Anal. Biochem. 402 , 129-136, (2010)

Nitric oxide (NO) mediates intercellular signaling through activation of its receptor, soluble guanylyl cyclase (sGC), leading to elevation of intracellular guanosine 3',5'-cyclic monophosphate (cGMP)...

 Synonyms

Adenosine 3',5'-phosphoric acid 2'-hydrogen butanedioate
2'-O-MONOSUCCINYLADENOSINE 3':5'-*CYCLIC MONOPHOSPH
succinyladenosine 3',5'-cyclic monophosphate