2'-O-Succinyl-cAMP

Names

[ Name ]:
2'-O-Succinyl-cAMP

[Synonym ]:
Adenosine 3',5'-phosphoric acid 2'-hydrogen butanedioate
2'-O-MONOSUCCINYLADENOSINE 3':5'-*CYCLIC MONOPHOSPH
succinyladenosine 3',5'-cyclic monophosphate

Biological Activity

[Description]:

2'-O-Succinyl-cAMP is a cAMP analog that can be covalently coupled to acetylcholinesterase. 2'-O-Succinyl-cAMP conjugate has been used as tracers in a classical heterogeneous competitive enzyme immunoassay allowing the determination of cAMP[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Pradelles P, et, al. Enzyme immunoassays of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate using acetylcholinesterase. Anal Chem. 1989 Mar 1;61(5):447-53.

[2]. Luttrell BM, et, al. Reaction coupling of chelation and antigen binding in the calcium ion-dependent antibody binding of cyclic AMP. J Biol Chem. 1991 Nov 15;266(32):21626-30.

Chemical & Physical Properties

[ Density]:
2.16g/cm3

[ Boiling Point ]:
781.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₁₆N₅O₉P

[ Molecular Weight ]:
429.27900

[ Flash Point ]:
426.3ºC

[ Exact Mass ]:
429.06900

[ PSA ]:
208.02000

[ LogP ]:
0.17950

[ Index of Refraction ]:
1.849

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells.

Endocrinology 151 , 2151-2161, (2010)

In the adrenal cortex, the biosynthesis of steroid hormones is controlled by the pituitary-derived hormone ACTH. The functions of ACTH are principally relayed by activating cAMP-dependent signaling pa...

Different role of cAMP dependent protein kinase and CaMKII in H3 receptor regulation of histamine synthesis and release

Neuroscience 164 , 1244-1251, (2009)

Histamine H3 autoreceptors induce a negative feedback on histamine synthesis and release. While it is known that cAMP/cAMP dependent protein kinase (PKA) and Ca2+/CaMKII transduction pathways mediate ...

A real-time fluorescent assay of the purified nitric oxide receptor, guanylyl cyclase.

Anal. Biochem. 402 , 129-136, (2010)

Nitric oxide (NO) mediates intercellular signaling through activation of its receptor, soluble guanylyl cyclase (sGC), leading to elevation of intracellular guanosine 3',5'-cyclic monophosphate (cGMP)...