N-Ethyl-2-pyrrolidone
N-Ethyl-2-pyrrolidone structure
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Common Name | N-Ethyl-2-pyrrolidone | ||
|---|---|---|---|---|
| CAS Number | 2687-91-4 | Molecular Weight | 113.158 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 203.6±0.0 °C at 760 mmHg | |
| Molecular Formula | C6H11NO | Melting Point | < -120 °C | |
| MSDS | Chinese USA | Flash Point | 76.1±0.0 °C | |
| Symbol |
GHS05, GHS08 |
Signal Word | Danger | |
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Triptolide treatment reduces Alzheimer's disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD.
Dis. Model Mech. 7(12) , 1385-95, (2014) The complex pathogenesis of Alzheimer's disease (AD) involves multiple contributing factors, including amyloid β (Aβ) peptide accumulation, inflammation and oxidative stress. Effective therapeutic strategies for AD are still urgently needed. Triptolide is the... |
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Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells.
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Molecular Neurodegeneration 10 , 56, (2015) Insulin degrading enzyme (IDE) is a major protease of amyloid beta peptide (Aβ), a prominent toxic protein in Alzheimer's disease (AD) pathogenesis. Previous studies suggested that statins promote IDE secretion; however, the underlying mechanism is unknown, a... |
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A novel method for determining the solubility of small molecules in aqueous media and polymer solvent systems using solution calorimetry.
Pharm. Res. 31(7) , 1735-43, (2014) To explore the application of solution calorimetry for measuring drug solubility in experimentally challenging situations while providing additional information on the physical properties of the solute material.A semi-adiabatic solution calorimeter was used t... |
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Effect of trichostatin A on gelsolin levels, proteolysis of amyloid precursor protein, and amyloid beta-protein load in the brain of transgenic mouse model of Alzheimer's disease.
Curr. Alzheimer Res. 11(10) , 1002-11, (2014) In vivo and in vitro studies have shown that gelsolin is an anti-amyloidogenic protein. Trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, promotes the expression of gelsolin. Fibrillized amyoid beta-protein (Aβ) is a key constituent of amyloid pla... |
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Acta Histochem. 117(1) , 83-91, (2015) Hyaluronidase 1 (HYAL1) and hyaluronidase 2 (HYAL2) are the major hyaluronidases acting synergistically to degrade hyaluronan (HA). In the kidney, HA is distributed heterogeneously. Our goal was to determine the consequences of a lack of either HYAL1 or HYAL2... |
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Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats.
J. Cell. Mol. Med. 16 , 2754-67, (2012) Alzheimer's disease (AD) and cerebral ischaemia share similar features in terms of altered amyloid precursor protein (APP) processing and β-amyloid (Aβ) accumulation. We have previously shown that Aβ and calcium deposition, and β-secretase activity, are robus... |