N-Desalkylflurazepam
N-Desalkylflurazepam structure
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Common Name | N-Desalkylflurazepam | ||
|---|---|---|---|---|
| CAS Number | 2886-65-9 | Molecular Weight | 288.704 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 463.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C15H10ClFN2O | Melting Point | 204-206°C | |
| MSDS | Chinese USA | Flash Point | 234.1±31.5 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs.
Xenobiotica 44(10) , 893-901, (2014) 1. The pharmacokinetics of acetaminophen (marker of gastric emptying), antipyrine (marker of hepatic metabolic activity and total body water), diazepam (lipophilic and highly distributed), diphenhydramine (hepatic blood flow-limited and alpha-1 acid glycoprot... |
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Cleaning up blood samples using a modified "QuEChERS" procedure for the determination of drugs of abuse and benzodiazepines by UPLC-MSMS(☆).
Forensic Sci. Int. 243 , 99-106, (2014) The "QuEChERS" (quick, easy, cheap, effective, rugged, and safe) dispersive SPE (dSPE) method is an emerging sample preparation technique that is becoming increasingly popular in the area of multi-residue pesticide analysis in food and agricultural products. ... |
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Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014) • The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail. |
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Solid-phase dispersive extraction method for analysis of benzodiazepine drugs in serum and urine samples.
J. Pharm. Biomed. Anal. 100 , 28-32, (2014) A simple yet highly efficient pretreatment method called solid-phase dispersive extraction (SPDE) was developed and used in combination with liquid chromatography/time-of-flight mass spectrometry (LC/TOF-MS) for the analysis of benzodiazepines (BZPs) in serum... |
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Analysis of benzodiazepines and their metabolites using DBS cards and LC-MS/MS.
Forensic Sci. Int. 255 , 137-45, (2015) Dried Blood Spot (DBS) has been used a blood extraction method for inherited metabolic disorder screening since 1960s. With introduction of LC-MS/MS, not only DBS could be used to analysis drugs in small blood volume, but in various fields, such as toxicology... |
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The disposition and metabolism of a hypnotic benzodiazepine, quazepam, in the hamster and mouse.
Drug Metab. Dispos. 12(4) , 452-9, (1984) The disposition of 14C-quazepam (7-chloro-(2,2,2-trifluoroethyl) [5-14C]-5-o-fluorophenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-thione), a new benzodiazepine hypnotic, was studied in hamsters and mice after iv and po dosing. In both species, quazepam was rapidly... |
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Inhibitory effect on 3H-diazepam binding and potentiating action on GABA of ethyl loflazepate, a new minor tranquilizer.
Jpn. J. Pharmacol. 37(4) , 373-9, (1985) A new benzodiazepine compound, ethyl loflazepate (ethyl-7-chloro-2,3-dihydro-5-(2-fluorophenyl)-2-oxo-1H,1,4- benzodiazepine-3-carboxylate; CM6912) was studied using in vitro experimental systems for its displacement activity on 3H-diazepam binding to the syn... |
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Effects of itraconazole on the plasma kinetics of quazepam and its two active metabolites after a single oral dose of the drug.
Ther. Drug Monit. 25(4) , 473-7, (2003) The effects of itraconazole, a potent inhibitor of cytochrome P450 (CYP) 3A4, on the plasma kinetics of quazepam and its two active metabolites after a single oral dose of the drug were studied. Ten healthy male volunteers received itraconazole 100 mg/d or pl... |
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The respiratory effects of oral ethyl loflazepate in volunteers.
Br. J. Clin. Pharmacol. 23(2) , 183-7, (1987) A volunteer study was undertaken to assess the respiratory effects of ethyl loflazepate, a new benzodiazepine, and to correlate these with plasma concentrations of the active metabolites. Twelve volunteers were given placebo, 2 mg ethyl loflazepate, and 6 mg ... |
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Propranolol does not alter flutoprazepam kinetics and metabolism in the rat.
Eur. J. Drug Metab. Pharmacokinet. 16(1) , 53-8, (1991) The influence of propranolol on the disposition of flutoprazepam, a benzodiazepine derivative extensively biotransformed by hepatic microsomal oxidation, was evaluated in the rat. Propranolol was infused subcutaneously with osmotic minipumps (5 mg/day) to obt... |