UNII:596C064IG4
UNII:596C064IG4 structure
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Common Name | UNII:596C064IG4 | ||
|---|---|---|---|---|
| CAS Number | 106-87-6 | Molecular Weight | 140.180 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 227.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C8H12O2 | Melting Point | -109ºC | |
| MSDS | Chinese USA | Flash Point | 86.4±12.3 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Two-photon excited fluorescence imaging of endogenous contrast in a mouse model of ovarian cancer.
Lasers Surg. Med. 45(3) , 155-66, (2013) Ovarian cancer has an extremely high mortality rate resulting from poor understanding of the disease. In order to aid understanding of disease etiology and progression, we identify the endogenous fluorophores present in a mouse model of ovarian cancer and des... |
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Effect of phosphatidylinositol-3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz[a]anthracene in neonatal rat ovaries.
Toxicol. Appl. Pharmacol. 241 , 127-34, (2009) 4-vinylcyclohexene diepoxide (VCD) is an ovotoxicant that specifically destroys primordial and small primary follicles in the ovaries of mice and rats. In contrast, 7,12-dimethylbenz[a]anthracene (DMBA) is ovotoxic to all ovarian follicle classes. This study ... |
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Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis.
Cancer Biol. Ther. 10(5) , 438-47, (2010) Determining if an ovarian mass is benign or malignant is an ongoing clinical challenge. The development of reliable animal models provides means to evaluate new diagnostic tools to more accurately determine if an ovary has benign or malignant features. Althou... |
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Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 297(3) , R587-92, (2009) Factors comprising the metabolic syndrome occur with increased incidence in postmenopausal women. To investigate the effects of ovarian failure on the progression of the metabolic syndrome, female B(6)C(3)F(1) mice were treated with 4-vinylcyclohexene diepoxi... |
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Midkine, a heparin-binding protein, is increased in the diabetic mouse kidney postmenopause.
Am. J. Physiol. Renal Physiol. 300(1) , F139-46, (2011) Estrogen is thought to protect against the development of chronic kidney disease, and menopause increases the development and severity of diabetic kidney disease. In this study, we used streptozotocin (STZ) to induce diabetes in the 4-vinylcyclohexene diepoxi... |
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Accelerated ovarian failure: a novel, chemically induced animal model of menopause.
Brain Res. 1379 , 176-87, (2011) Current rodent models of menopause fail to adequately recapitulate the menopause transition. The intact aging model fails to achieve very low estrogen levels, and the ovariectomy model lacks a perimenopause phase. A new rodent model of accelerated ovarian fai... |
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Distribution and responsiveness of rat anti-Müllerian hormone during ovarian development and VCD-induced ovotoxicity.
Toxicol. Appl. Pharmacol. 249(1) , 1-7, (2010) Anti-Müllerian hormone (AMH) is produced by granulosa cells in primary to small antral follicles of the adult ovary and helps maintain primordial follicles in a dormant state. The industrial chemical, 4-vinylcyclohexene diepoxide (VCD) causes specific ovotoxi... |
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Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis).
Comp. Med. 60(5) , 380-8, (2010) Chronic diseases including coronary heart disease and osteoporosis represent a substantial health burden to postmenopausal women, yet the initiation of these conditions and their relationships with reproductive aging remain poorly understood. This situation i... |
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7,12-dimethylbenz[a]anthracene induces sertoli-leydig-cell tumors in the follicle-depleted ovaries of mice treated with 4-vinylcyclohexene diepoxide.
Comp. Med. 60(1) , 10-7, (2010) Ovarian cancer is associated with high mortality due to its late onset of symptoms and lack of reliable screening methods for early detection. Furthermore, the incidence of ovarian cancer is higher in postmenopausal women. Mice rendered follicle-depleted thro... |
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Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes.
Comp. Med. 59(1) , 46-59, (2009) Young rats treated daily with intraperitoneal 4-vinylcyclohexene diepoxide (VCD) undergo selective destruction of primordial follicles, resulting in gradual ovarian failure resembling the menopausal transition in women. To determine whether VCD has similar ef... |