Secalciferol

Secalciferol Structure
Secalciferol structure
Common Name Secalciferol
CAS Number 55721-11-4 Molecular Weight 416.637
Density 1.1±0.1 g/cm3 Boiling Point 571.1±35.0 °C at 760 mmHg
Molecular Formula C27H44O3 Melting Point 63-65ºC
MSDS Chinese USA Flash Point 241.5±20.5 °C
Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger

Interdependence and contributions of sun exposure and vitamin D to MRI measures in multiple sclerosis.

J. Neurol. Neurosurg. Psychiatr. 84(10) , 1075-81, (2013)

To assess the relationships of sun exposure history, supplementation and environmental factors to vitamin D levels in multiple sclerosis (MS) patients and to evaluate the associations between sun exposure and MRI measures.This study included 264 MS patients (...

Dietary vitamin D inadequacy accelerates calcification and osteoblast-like cell formation in the vascular system of LDL receptor knockout and wild-type mice.

J. Nutr. 144(5) , 638-46, (2014)

Vitamin D insufficiency is highly associated with cardiovascular morbidity and mortality. We have demonstrated enhanced vascular calcification in LDL receptor knockout (LDLR(-/-)) mice fed a diet low in vitamin D. This study aimed to investigate the impact of...

Anti-inflammatory effect of vitamin D on gingivitis: a dose-response randomised control trial.

Oral Health Prev. Dent. 11(1) , 61-9, (2013)

To assess the anti-inflammatory effect of vitamin D on gingivitis at various doses.In this randomized controlled trial, daily oral vitamin D supplementation was given in doses of 2000 IU for group A, 1000 IU for group B, 500 IU for group C and a placebo for g...

Breaking down the vitamin D-GFR relationship.

Am. J. Kidney Dis. 64(2) , 168-70, (2014)

Incidence and risk factors of vitamin D deficiency in critically ill patients: results from a prospective observational study.

Intensive Care Med. 36(9) , 1609-11, (2010)

Markers of the APC/β-catenin signaling pathway as potential treatable, preneoplastic biomarkers of risk for colorectal neoplasms.

Cancer Epidemiol. Biomarkers Prev. 21(6) , 969-79, (2012)

Malfunctioning of the adenomatous polyposis coli (APC)/β-catenin signaling pathway is both an early and common event in sporadic colorectal cancer. To assess the potential of APC/β-catenin signaling pathway markers as treatable, preneoplastic biomarkers of ri...

Short-term individual nutritional care as part of routine clinical setting improves outcome and quality of life in malnourished medical patients.

Clin. Nutr. 30(2) , 194-201, (2011)

Strategies to treat malnutrition lack practicability in the hospital setting. The present study aimed at developing and evaluating a routinely manageable concept for an improved nutritional care of malnourished in-hospital patients.A randomized controlled int...

Expression of human CYP27B1 in Escherichia coli and characterization in phospholipid vesicles.

FEBS J. 279(19) , 3749-61, (2012)

CYP27B1 is a mitochondrial cytochrome P450 that catalyses the hydroxylation of 25-hydroxyvitamin D3 at the C1α-position to give the hormonally active form of vitamin D3, 1α,25-dihydroxyvitamin D3. We successfully expressed human CYP27B1 in Escherichia coli an...

Simultaneous measurement of plasma vitamin D(3) metabolites, including 4β,25-dihydroxyvitamin D(3), using liquid chromatography-tandem mass spectrometry.

Anal. Biochem. 418(1) , 126-33, (2011)

Simultaneous and accurate measurement of circulating vitamin D metabolites is critical to studies of the metabolic regulation of vitamin D and its impact on health and disease. To that end, we have developed a specific liquid chromatography-tandem mass spectr...

Peripheral blood regulatory T cell measurements correlate with serum vitamin D levels in patients with multiple sclerosis.

J. Neuroimmunol. 213(1-2) , 135-41, (2009)

Vitamin D has been associated with a decreased risk of multiple sclerosis (MS). In this study, serum 1, 25-dihydroxyvitamin D (1, 25-(OH)2 vitD) and 25-hydroxyvitamin D (25-OH vitD), regulatory T cell percentages and naïve and memory T helper cell subsets wer...