Sodium 1-pyrrolidinecarbodithioate
Sodium 1-pyrrolidinecarbodithioate structure
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Common Name | Sodium 1-pyrrolidinecarbodithioate | ||
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| CAS Number | 872-71-9 | Molecular Weight | 169.243 | |
| Density | 1.264g/cm3 | Boiling Point | 199.7ºC at 760 mmHg | |
| Molecular Formula | C5H8NNaS2 | Melting Point | >300℃ | |
| MSDS | Chinese USA | Flash Point | 74.6ºC | |
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PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway
Exp. Cell Res. 319(10) , 1523-33, (2013) The ligand-activated transcription factor peroxisome proliferator-activated receptor-α (PPARα) participates in the regulation of cellular inflammation. More recent studies indicated that sirtuin1 (SIRT1), a NAD+-dependent deacetylase, regulates the inflammato... |
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Lidocaine attenuates lipopolysaccharide-induced inflammatory responses in microglia
J. Surg. Res. 192(1) , 150-62, (2014) Background Lidocaine has been used as a local anesthetic with anti-inflammatory properties, but its effects on neuroinflammation have not been well defined. In the present study, we investigated the prophylactic effects of lidocaine on lipopolysaccharide (LPS... |
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Interleukin-1 induction of aggrecanase gene expression in human articular chondrocytes is mediated by mitogen-activated protein kinases.
Cell Physiol. Biochem. 30(3) , 563-74, (2012) We investigated the unknown molecular mechanisms of Interleukin-1 (IL-1β)-induced cartilage aggrecan degeneration by aggrecanase (ADAMTS-A Disintegrin And Metalloproteinase with ThromboSpondin motifs) in human articular chondrocytes, a model mimicking human a... |
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Reduced NO production rapidly aggravates renal function through the NF-κB/ET-1/ETA receptor pathway in DOCA-salt-induced hypertensive rats.
Life Sci. 91(13-14) , 644-50, (2012) It has been reported that endothelin-1 (ET-1) overproduction and reduced nitric oxide (NO) production are closely related to the progression of renal diseases. In the present study, we examined the interrelation between ET-1 and NO system using rats treated w... |
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Norepinephrine activates NF-κB transcription factor in cultured rat pineal gland.
Life Sci. 94(2) , 122-9, (2014) The circadian rhythm in mammalian pineal melatonin secretion is modulated by norepinephrine (NE) released at night. NE interaction with β1-adrenoceptors activates PKA that phosphorylates the transcription factor CREB, leading to the transcription and translat... |
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NF-κB-mediated inverse regulation of fractalkine and CX3CR1 during CLP-induced sepsis.
Cytokine 61(1) , 97-103, (2013) Fractalkine is a unique member of the CX3C chemokine family by unfolding its potential through the chemokine (C-X3-C motif) receptor 1 (CX3CR1) with dual function acting both as an adhesion molecule and a soluble chemokine. The regulation of this chemokine is... |
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p38-NF-κB-promoted mitochondria-associated apoptosis and G2/M cell cycle arrest in norcantharidin-treated HeLa cells.
J. Asian Nat. Prod. Res. 14(11) , 1008-19, (2012) Previous study proved that norcantharidin (NCTD) could exert its anticancer activity in a variety of malignant cell lines, including human cervical carcinoma HeLa cells. In this study, we found that NCTD-activated p38 mitogen-activated protein kinase (p38 MAP... |
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Myocardial infarction induces sympathetic hyperinnervation via a nuclear factor-κB-dependent pathway in rabbit hearts.
Neurosci. Lett. 535 , 128-33, (2013) Cardiac sympathetic hyperinnervation after myocardial infarction (MI) is associated with a high incidence of lethal arrhythmia. However, the mechanisms of nerve sprouting induced by MI are unclear. In this study, we showed a nuclear factor-κB (NF-κB) signalin... |
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Inhibition of NF-kappaB activation by Pyrrolidine dithiocarbamate partially attenuates hippocampal MMP-9 activation and improves cognitive deficits in streptozotocin-induced diabetic rats.
Behav. Brain Res. 238 , 44-7, (2013) Matrix metalloproteinase-9 (MMP-9) has been found at significantly increased activity and also contributes to blood-brain barrier degradation in diabetes. Activation of NF-κB pathway is associated with diabetes-induced cognitive impairment, and MMP-9 gene pro... |
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The anti-inflammatory potential of neuropeptide FF in vitro and in vivo.
Peptides 47 , 124-32, (2013) Neuropeptide FF (NPFF) has many functions in regulating various biological processes. However, little attention has been focused on the anti-inflammatory effect of this peptide. In the present study, the in vitro anti-inflammatory activity of NPFF in both pri... |