Journal of Surgical Research 2002-01-01

Lidocaine attenuates lipopolysaccharide-induced inflammatory responses in microglia

Tong Yuan, Zhiwen Li, Xinbai Li, Gaoqi Yu, Na Wang, Xige Yang

Index: J. Surg. Res. 192(1) , 150-62, (2014)

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Abstract

Background Lidocaine has been used as a local anesthetic with anti-inflammatory properties, but its effects on neuroinflammation have not been well defined. In the present study, we investigated the prophylactic effects of lidocaine on lipopolysaccharide (LPS)-activated microglia and explored the underlying mechanisms.