Ammonium 1-pyrrolidinedithiocarbamate

Modify Date: 2024-01-02 19:08:49

Ammonium 1-pyrrolidinedithiocarbamate Structure
Ammonium 1-pyrrolidinedithiocarbamate structure
 Common Name Ammonium 1-pyrrolidinedithiocarbamate
CAS Number 5108-96-3 Molecular Weight 164.292
Density 1.264g/cm3 Boiling Point 199.7ºC at 760 mmHg
Molecular Formula C5H12N2S2 Melting Point 153-155 °C(lit.)
MSDS Chinese USA Flash Point 74.6ºC

 Use of Ammonium 1-pyrrolidinedithiocarbamate


Pyrrolidinedithiocarbamate ammonium is a selective NF-κB inhibitor.

 Names

Name Ammonium 1-pyrrolidinedithiocarbamate
Synonym More Synonyms

 Ammonium 1-pyrrolidinedithiocarbamate Biological Activity

Description Pyrrolidinedithiocarbamate ammonium is a selective NF-κB inhibitor.
Related Catalog
Target

NF-κB
In Vitro Pretreatment of cells with pyrrolidinedithiocarbamate (3-1000 μM) dose-dependently attenuate IL-8 production. Furthermore, pyrrolidinedithiocarbamate (100 μM) suppresses the accumulation of IL-8 mRNA. Pyrrolidinedithiocarbamate inhibits the activation of NF-κB, because pyrrolidinedithiocarbamate suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate decrease IL-8 production by intestinal epithelial cells[1].
In Vivo The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis[2].
Cell Assay The human colon cancer cell line HT-29 is obtained and cells are grown in modified McCoy’s 5A medium supplemented with 10% fetal bovine serum. To study the effect of pyrrolidinedithiocarbamate ammonium on IL-8 production, HT-29 cells in 96-well plates are induced with 20 ng/mL of IL-1β for 18 h. Various concentrations (3-1000 μM) of pyrrolidinedithiocarbamate or its vehicle (culture medium) are added to the cells 30 min prior to IL-1β stimulation. The concentration of IL-8 in the supernatant is determined using solid-phase enzyme-linked immunosorbent assay[1].
Animal Admin Animal Administration: [2]Pyrrolidinedithiocarbamate is administered intraperitoneally to mice at dose levels of 100 and 50 mg/kg. Mice are divided into a DSS-untreated group (normal group), DSS-treated control group, DSS+pyrrolidinedithiocarbamate-treated groupI (low-dose group), and DSS+pyrrolidinedithiocarbamate-treated groupII (high-dose group). In each group, the disease activity index score (DAI score), intestinal length, histological score, and the levels of activated NF-κB and inflammatory cytokines (IL-1β and TNF-α) in tissue are measured[2].
References

[1]. Németh ZH, et al. Pyrrolidinedithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells. Immunol Lett. 2003 Jan 2;85(1):41-6.

[2]. Qin JD, et al. Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and CYP2E1 content of rats with immunological liver injury. Pharm Biol. 2014 Nov;52(11):1460-1466.

 Chemical & Physical Properties

Density 1.264g/cm3
Boiling Point 199.7ºC at 760 mmHg
Melting Point 153-155 °C(lit.)
Molecular Formula C5H12N2S2
Molecular Weight 164.292
Flash Point 74.6ºC
Exact Mass 164.044189
PSA 77.37000
LogP 1.55870
Storage condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility 50 g/L (20 ºC)

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R22;R36/37/38
Safety Phrases S26-S36-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29339990

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

1-Pyrrolidinecarbodithioic acid,ammonium salt
EINECS 225-834-4
Pyrrolindinedithiocarbamate ammonium
1-Pyrrolidinecarbodithioic acid ammoniate (1:1)
Ammonium Pyrrolidine-N-dithiocarbamate
ammonium tetramethylenedithiocarbamate
Pyrrolidine-N-dithiocarbamic Acid Ammonium Salt
Ammonium 1-pyrrolidinedithiocarboxylate
APDTC AMMONIUM SALT
Ammonium pyrrolidinecarbodithioate
MFCD00012720
APCD
PDTC,NH4
PYRROLIDINEDITHIOCARBAMATE
APDTC
1-PYRROLIDINECARBODITHIOIC ACID AMMONIUM SALT
QX 314 chloride
pyrrolidine-1-dithiocarboxylic acid ammonium salt
Ammonium pyrrolidine
1-Pyrrolidinecarbodithioic acid, ammonuim salt
Ammonium pyrrolidine dithiocarbamate
Pyrrolidinedithiocarbamic acid ammonium salt
APDC
Ammonium 1-Pyrrolidinecarbodithioate
1-PYRROLIDINECARBODITHIOIC ACID
Pyrrolidinedithiocarbamate ammonium
APDC AMMONIUM SALT
Ammonium 1-pyrrolidinedithiocarbamate
Ammoniumpyrrolidinedithiocarb
Ammonium pyrrolidine-1-carbodithioate
1-Pyrrolidinecarbodithioic acid, ammonium salt
1-Pyrrolidinecarbodithioic acid ammonium salt,APDC,Ammonium pyrrolidinecarbodithioate
Ammonium pyrrolidinedithiocarbamate
Pyrrolidinedithiocarbamate (ammonium)
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