DL-Lysine
DL-Lysine structure
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Common Name | DL-Lysine | ||
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| CAS Number | 70-54-2 | Molecular Weight | 146.188 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 311.5±32.0 °C at 760 mmHg | |
| Molecular Formula | C6H14N2O2 | Melting Point | 170ºC (dec.) | |
| MSDS | USA | Flash Point | 142.2±25.1 °C | |
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The protein phosphatase Siw14 controls caffeine-induced nuclear localization and phosphorylation of Gln3 via the type 2A protein phosphatases Pph21 and Pph22 in Saccharomyces cerevisiae.
J. Biochem. 157(1) , 53-64, (2015) The Saccharomyces cerevisiae Siw14, a tyrosine phosphatase involved in the response to caffeine, participates in regulation of the phosphorylation and intracellular localization of Gln3, a GATA transcriptional activator of nitrogen catabolite repression-sensi... |
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Functional study of the Hap4-like genes suggests that the key regulators of carbon metabolism HAP4 and oxidative stress response YAP1 in yeast diverged from a common ancestor.
PLoS ONE 9(12) , e112263, (2014) The transcriptional regulator HAP4, induced by respiratory substrates, is involved in the balance between fermentation and respiration in S. cerevisiae. We identified putative orthologues of the Hap4 protein in all ascomycetes, based only on a conserved sixte... |
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The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.
Sci. Signal. 8(364) , ra18, (2015) Factors secreted by tumor cells shape the local microenvironment to promote invasion and metastasis, as well as condition the premetastatic niche to enable secondary-site colonization and growth. In addition to this secretome, tumor cells have increased abund... |
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In vitro inhibition of lysine decarboxylase activity by organophosphate esters.
Biochem. Pharmacol. 92(3) , 506-16, (2014) Organophosphate esters (OPEs), a major group of organophosphorus flame retardants, are regarded as emerging environmental contaminants of health concern. Amino acid decarboxylases catalyze the conversion of amino acids into polyamines that are essential for c... |
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AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.
Nat. Cell Biol. 17(1) , 20-30, (2014) Inhibition of a main regulator of cell metabolism, the protein kinase mTOR, induces autophagy and inhibits cell proliferation. However, the molecular pathways involved in the cross-talk between these two mTOR-dependent cell processes are largely unknown. Here... |
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Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1.
Blood 124(18) , 2767-74, (2014) Telomerase is a ribonucleoprotein enzyme that is necessary for overcoming telomere shortening in human germ and stem cells. Mutations in telomerase or other telomere-maintenance proteins can lead to diseases characterized by depletion of hematopoietic stem ce... |
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Application of fluorescence two-dimensional difference in-gel electrophoresis as a proteomic biomarker discovery tool in muscular dystrophy research.
Biology (Basel.) 2(4) , 1438-64, (2014) In this article, we illustrate the application of difference in-gel electrophoresis for the proteomic analysis of dystrophic skeletal muscle. The mdx diaphragm was used as a tissue model of dystrophinopathy. Two-dimensional gel electrophoresis is a widely emp... |
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The PHD finger of p300 influences its ability to acetylate histone and non-histone targets.
J. Mol. Biol. 426(24) , 3960-72, (2014) In enzymes that regulate chromatin structure, the combinatorial occurrence of modules that alter and recognise histone modifications is a recurrent feature. In this study, we explored the functional relationship between the acetyltransferase domain and the ad... |
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HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer.
PLoS ONE 9(12) , e115228, (2014) HSP90 inhibitors are currently undergoing clinical evaluation in combination with antimitotic drugs in non-small cell lung cancer (NSCLC), but little is known about the cellular effects of this novel drug combination. Therefore, we investigated the molecular ... |
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Direct recognition of the C-terminal polylysine residues of nonstop protein by Ltn1, an E3 ubiquitin ligase.
Biochem. Biophys. Res. Commun. 453(3) , 642-7, (2014) When mRNAs lack stop codons, errors in gene expression and coding of aberrant proteins that are harmful in cells can result. In Saccharomyces cerevisiae, a 180-kDa E3-ubiquitin ligase, Ltn1 has been known to associate with ribosomes and marks translationally-... |