Escin

Escin Structure
Escin structure
Common Name Escin
CAS Number 6805-41-0 Molecular Weight 2262.51000
Density 1.46 g/cm3 Boiling Point 1140.6ºC at 760 mmHg
Molecular Formula C55H86O24 Melting Point 224.5°C
MSDS Chinese USA Flash Point 311.8ºC
Symbol GHS07
GHS07
Signal Word Warning

Effect of beta-aescin extract from Chinese buckeye seed on chronic venous insufficiency.

Pharmazie 68(6) , 428-30, (2013)

The aim of this study was to explore the mechanism of domestic beta-aescin treating chronic venous insufficiency through observing its actions on the isolated canine saphenous venous tension, venous pressure, venous return and lymphatic return. The isolated c...

Interaction between titanium and cadmium in various guinea pig organs.

Biol. Trace Elem. Res. 151(2) , 209-16, (2013)

Titanium (Ti) is used in many fields, while cadmium (Cd) is known to cause the itai-itai disease. In the present study, possible interactions between titanium and cadmium were investigated. Aorta, taenia coli, and liver were removed from male guinea pigs. Mus...

Rho-kinase inhibition attenuates calcium-induced contraction in β-escin but not Triton X-100 permeabilized rabbit femoral artery.

J. Muscle Res. Cell Motil. 32(2) , 77-88, (2011)

K+-depolarization (KCl) of smooth muscle has long been known to cause Ca2+-dependent contraction, but only recently has this G protein-coupled receptor (GPCR)-independent stimulus been associated with rhoA kinase (ROCK)-dependent myosin light chain (MLC) phos...

Bioavailability of l-thyroxine and its metabolites after topical treatment with an emulsion containing 0.1% micronised l-thyroxine.

G. Ital. Dermatol. Venereol. 148(3) , 287-92, (2013)

Aim of the study was to assess systemic effects of a cycle of treatment with a topical formulation of l-T4 and escin (Somatoline®) in healthy women based on changes in bioavailability of FT4, FT3, rT3, and TSH.This study enrolled 20 healthy adult women with b...

[Efficacy of the anti-edema drug L-lysine aescinat in stroke].

Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova 112(12 Pt 2) , 31-4, (2012)

Forty-nine patients with ischemic hemispheric stroke admitted within 48 hours of stroke onset were studied. Twenty-nine patients (the main group) received L-lysine aescinat as an anti-edema drug. The efficacy was evaluated clinically and by EEG and autonomic ...

Mixture designs in the optimisation of PLGA nanoparticles: influence of organic phase composition on β-aescin encapsulation.

J. Microencapsul. 29(2) , 115-25, (2012)

The objective of this study was to enhance the encapsulation of the antileishmanial saponin aescin in poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs). We prepared the NPs by the O/W and W/O/W combined emulsification solvent evaporation/salting-out t...

[Effects of sodium aescinate on lipid peroxidiation injury induced by intestinal ischemia/reperfusion].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 27(1) , 17-8, 97, (2011)

[The pharmacology of escin, a saponin of Aesculus hippocastanum L. III. Pharmacokinetics and toxicology].

Boll. Chim. Farm. 131(8) , 320-1, (1992)

[Pharmacology of escin, a saponin of Aesculus hippocastanum L. II. Pharmacodynamics of escin. Chapter II].

Boll. Chim. Farm. 131(7) , 284-93, (1992)

[Pharmacology of escin, a saponin from Aesculus hyppocastanum L. II. Pharmacodynamics of escin. Chapter I].

Boll. Chim. Farm. 131(6) , 242-6, (1992)