Globotriose
Globotriose structure
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Common Name | Globotriose | ||
|---|---|---|---|---|
| CAS Number | 66580-68-5 | Molecular Weight | 504.43700 | |
| Density | 1.75 g/cm3 | Boiling Point | 968.5ºC at 760 mmHg | |
| Molecular Formula | C18H32O16 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 332.9ºC | |
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Carbosilane dendrimers bearing globotriaoses: syntheses of globotrioasyl derivative and introduction into carbosilane dendrimers.
Biomacromolecules 7(8) , 2274-83, (2006) As an application of a one-pot reaction involving Birch reduction and subsequent S(N)2 reaction in liquid ammonia, synthetic assembly of trisaccharidic moieties of globotriaosyl ceramide onto carbosilane dendrimers was accomplished using tris(3-bromopropyl)ph... |
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Efficient chemoenzymatic synthesis of globotriose and its derivatives with a recombinant alpha-(1-->4)-galactosyltransferase.
Carbohydr. Res. 337(11) , 969-76, (2002) A truncated alpha-(1-->4)-galactosyltransferase (LgtC) gene from Neisseria meningitidis was cloned. The recombinant glycosyltransferase was expressed in Escherichia coli BL21 (DE3) strain with high specific activity (5 units/mg protein). Its acceptor specific... |
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Structural analysis of the interaction between Shiga toxin B subunits and linear polymers bearing clustered globotriose residues.
Infect. Immun. 74(3) , 1984-8, (2006) We previously developed linear polymers bearing clustered trisaccharides of globotriaosylceramide (Gb3) as orally applicable Shiga toxin (Stx) neutralizers. Here, using a Gb3 polymer with a short spacer tethering the trisaccharide to the core, we found that s... |
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Determination of the cell adhesion specificity of Streptococcus suis with the complete set of monodeoxy analogues of globotriose.
Glycoconj. J. 16(1) , 67-71, (1999) Streptococcus suis causes meningitis and other serious infections in pigs and humans, and binds to host cell globotriosylceramide. In order to determine the essential hydroxyls involved in binding, the complete set of monodeoxy derivatives of the receptor tri... |
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Structure of extended lipopolysaccharide glycoforms containing two globotriose units in Haemophilus influenzae serotype b strain RM7004.
Biochemistry 42(15) , 4463-75, (2003) Lipopolysaccharide (LPS) is a major virulence determinant of the human bacterial pathogen Haemophilus influenzae. Structural elucidation of the LPS from H. influenzae type b strain RM7004 was achieved by using electrospray ionization mass spectrometry (ESI-MS... |
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In vitro and in vivo effects of soluble, monovalent globotriose on bacterial attachment and colonization.
Antimicrob. Agents Chemother. 49(9) , 3842-6, (2005) Epithelial cells lining the urinary tract are rich in globo series glycolipids, structurally defined by a Galalpha1,4Gal motif in the oligosaccharide moiety of this glycolipid family. This Galalpha1,4Gal motif is the attachment target for the P-fimbrial adhes... |
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A concise and practical synthesis of antigenic globotriose, alpha-D-Gal-(1-->4)-beta-D-Gal-(1-->4)-beta-D-Glc.
Carbohydr. Res. 341(9) , 1174-80, (2006) A concise and practical synthesis of the antigenic globotriose, alpha-D-Gal-(1-->4)-beta-D-Gal-(1-->4)-beta-D-Glc (13), was achieved by coupling of a monosaccharide donor, 3-O-allyl-2-O-benzoyl-4,6-O-benzylidene-alpha-D-galactopyranosyl trichloroacetimidate (... |
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Overexpression and biochemical characterization of beta-1,3-N-acetylgalactosaminyltransferase LgtD from Haemophilus influenzae strain Rd.
Biochem. Biophys. Res. Commun. 295(1) , 1-8, (2002) The lipopolysaccharide of capsule deficient Haemophilus influenzae strain Rd contains an N-acetylgalactosamine residue attached to the terminal globotriose moiety in the Hex5 glycoform. Genome analysis identified an open reading frame HI1578, referred to as l... |
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Occurrence of a unique sialyl tetrasaccharide in colostrum of a bottlenose dolphin (Tursiops truncatus).
Biochim. Biophys. Acta 1725(3) , 290-7, (2005) Crude oligosaccharides were recovered from bottlenose dolphin (Tursiops truncatus) colostrum after chloroform/methanol extraction of lipids and protein precipitation, and purified using gel filtration, anion exchange chromatography and high performance liquid... |
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Synthesis of oligosaccharides by bacterial enzymes.
Glycoconj. J. 16(2) , 141-6, (1999) Many human pathogens initiate disease by utilizing their microbial adhesin proteins to attach to glycoconjugates on host cell mucosal surfaces. Soluble oligosaccharides of identical or similar structure to these naturally occurring ligands can both prevent ba... |