XAV-939
XAV-939 structure
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Common Name | XAV-939 | ||
|---|---|---|---|---|
| CAS Number | 284028-89-3 | Molecular Weight | 312.310 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 429.3ºC at 760 mmHg | |
| Molecular Formula | C14H11F3N2OS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 213.4ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Down regulation of Wnt signaling mitigates hypoxia-induced chemoresistance in human osteosarcoma cells.
PLoS ONE 9(10) , e111431, (2014) Osteosarcoma (OS) is the most common type of solid bone cancer and remains the second leading cause of cancer-related death for children and young adults. Hypoxia is an element intrinsic to most solid-tumor microenvironments, including that of OS, and is asso... |
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XAV939 inhibits the stemness and migration of neuroblastoma cancer stem cells via repression of tankyrase 1.
Int. J. Oncol. 45(1) , 121-8, (2014) Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. One fundamental issue regarding NB recurrence and metastasis is the maintenance of cancer stem cells (CSCs) stemness. Tankyrase 1 (TNKS1) is overexpressed in several types of cancers... |
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Targeting c-Met in melanoma: mechanism of resistance and efficacy of novel combinatorial inhibitor therapy.
Cancer Biol. Ther. 15(9) , 1129-41, (2014) Numerous tyrosine kinase inhibitors (TKIs) targeting c-Met are currently in clinical trials for several cancers. Their efficacy is limited due to the development of resistance. The present study aims to elucidate this mechanism of c-Met TKI resistance by inve... |
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Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM.
Development 141(24) , 4806-16, (2014) During somitogenesis, epithelial somites form from the pre-somitic mesoderm (PSM) in a periodic manner. This periodicity is regulated by a molecular oscillator, known as the 'segmentation clock', that is characterised by an oscillatory pattern of gene express... |
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Cdo suppresses canonical Wnt signalling via interaction with Lrp6 thereby promoting neuronal differentiation.
Nat. Commun. 5 , 5455, (2014) Canonical Wnt signalling regulates expansion of neural progenitors and functions as a dorsalizing signal in the developing forebrain. In contrast, the multifunctional co-receptor Cdo promotes neuronal differentiation and is important for the function of the v... |
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Tankyrases regulate glucoregulatory mechanisms and somatic growth via the central melanocortin system in zebrafish larvae.
FASEB J. 29 , 4435-48, (2015) The central melanocortin system is a key regulator of energy homeostasis. Recent studies indicate that tankyrases (TNKSs), which poly(ADP-ribosyl)ate target proteins and direct them toward proteasomal degradation, affect overall metabolism, but the exact mole... |
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WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes.
Antioxid. Redox Signal. 22(7) , 555-71, (2015) Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a master regulator of oxidant and xenobiotic metabolism, but it is unknown how it is regulated to provide basal expression of this defense system. Here, we studied the putative connection between NRF2 and ... |
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A Molecular atlas of Xenopus respiratory system development.
Dev. Dyn. 244(1) , 69-85, (2014) Respiratory system development is regulated by a complex series of endoderm-mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early respiratory system development, but the extent to which ... |
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Generation of eye field/optic vesicle-like structures from human embryonic stem cells under two-dimensional and chemically defined conditions.
In Vitro Cell. Dev. Biol. Anim. 51(3) , 310-8, (2015) Despite the enormous progress in studying retinal cell differentiation from human embryonic stem cells (hESCs), none of the reported protocols have produced a cost-effective eye field cells with the capability to further differentiate into retinal derivatives... |
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Robust Generation of Cardiomyocytes from Human iPS Cells Requires Precise Modulation of BMP and WNT Signaling.
Stem Cell Rev. 11 , 560-9, (2015) Various strategies have been published enabling cardiomyocyte differentiation of human induced pluripotent stem (iPS) cells. However the complex nature of signaling pathways involved as well as line-to-line variability compromises the application of a particu... |