NoMifensine
NoMifensine structure
|
Common Name | NoMifensine | ||
|---|---|---|---|---|
| CAS Number | 32795-47-4 | Molecular Weight | 354.40000 | |
| Density | 1.114g/cm3 | Boiling Point | 378.4ºC at 760mmHg | |
| Molecular Formula | C20H22N2O4 | Melting Point | 179-181ºC | |
| MSDS | Chinese USA | Flash Point | 164ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Spectrofluorimetric determination of nomifensine in human plasma and urine by derivatization with fluorescamine.
Luminescence 27(1) , 80-3, (2012) A sensitive, simple and rapid spectrofluorimetric method was developed for the determination of nomifensine in human plasma and urine. The present method was based on the derivatization by fluorescamine in phosphate buffer at pH 4.0 to produce a highly fluore... |
|
|
The roles of dopamine transport inhibition and dopamine release facilitation in wake enhancement and rebound hypersomnolence induced by dopaminergic agents.
Sleep 32(11) , 1425-38, (2009) Rebound hypersomnolence (RHS: increased sleep following increased wake) is a limiting side-effect of many wake-promoting agents. In particular, RHS in the first few hours following wake appears to be associated with dopamine (DA)-releasing agents, e.g., amphe... |
|
|
Alcohol-induced depressive-like behavior is associated with cortical norepinephrine reduction.
Pharmacol. Biochem. Behav. 96(4) , 395-401, (2010) Although strong positive association between alcoholism and depression is a common epidemiological observance, the causal relationship and the neurobiological substrates of such observations are far from clear. We have reported that chronic daily exposure to ... |
|
|
Forced swim test behavior in postpartum rats.
Pharmacol. Biochem. Behav. 96(4) , 402-12, (2010) This study was undertaken to determine whether depression-like behavior can be observed in gonadally intact females that have experienced normal pregnancy. When tested on the forced swim test (FST) on postpartum days 1-7, previously pregnant rats spent slight... |
|
|
Evaluation of the effects and mechanisms of action of glufosinate, an organophosphate insecticide, on striatal dopamine release by using in vivo microdialysis in freely moving rats.
Arch. Toxicol. 84(10) , 777-85, (2010) The purpose of the present work was to assess the effects of glufosinate ammonium (GLA), an aminoacid structurally related to glutamate, on in vivo dopamine (DA) release from rat striatum, using brain microdialysis coupled to HPLC-EC. Intrastriatal administra... |
|
|
Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes.
Neuroscience 154(2) , 848-60, (2008) In the present study, we examined whether exposing rats to a high-dose regimen of manganese chloride (Mn) during the postnatal period would depress presynaptic dopamine functioning and alter nonassociative and associative behaviors. To this end, rats were giv... |
|
|
Inhibition of dopamine uptake by D2 antagonists: an in vivo study.
J. Neurochem. 116(3) , 449-58, (2011) D(2)-like antagonists potentiate dopamine release. They also inhibit dopamine uptake by a mechanism yet to be clarified. Here, we monitored dopamine uptake in the striatum of anesthetized mice. The dopamine overflow was evoked by brief electrical stimulation ... |
|
|
Identification of multiple glutathione conjugates of 8-amino- 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (nomifensine) in liver microsomes and hepatocyte preparations: evidence of the bioactivation of nomifensine.
Drug Metab. Dispos. 38(1) , 46-60, (2010) 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (nomifensine), an antidepressant drug, was withdrawn from the market because of increased incidence of hemolytic anemia, as well as kidney and liver toxicity. Although the nature of the potentia... |
|
|
Central administration of p-hydroxyamphetamine produces a behavioral stimulant effect in rodents: evidence for the involvement of dopaminergic systems.
Psychopharmacology 208(2) , 323-31, (2010) It is well-known that amphetamine induces increased locomotor activity in rodents. We previously found that intracerebroventricular (i.c.v.) administration of p-hydroxyamphetamine (p-OHA), an amphetamine metabolite, increases synaptic dopamine (DA) levels in ... |
|
|
In vitro metabolism studies of nomifensine monooxygenation pathways: metabolite identification, reaction phenotyping, and bioactivation mechanism.
Drug Metab. Dispos. 38(10) , 1767-78, (2010) Multiple GSH adducts of the oxidative products of nomifensine (M1-M9) in human hepatocytes and liver microsomes have been identified recently. The current study reports three new types of monooxygenated metabolites of nomifensine identified in human liver mic... |