prazepam
prazepam structure
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Common Name | prazepam | ||
|---|---|---|---|---|
| CAS Number | 2955-38-6 | Molecular Weight | 324.80400 | |
| Density | 1.31g/cm3 | Boiling Point | 538.5ºC at 760mmHg | |
| Molecular Formula | C19H17ClN2O | Melting Point | 145-146° | |
| MSDS | Chinese USA | Flash Point | 279.5ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Cleaning up blood samples using a modified "QuEChERS" procedure for the determination of drugs of abuse and benzodiazepines by UPLC-MSMS(☆).
Forensic Sci. Int. 243 , 99-106, (2014) The "QuEChERS" (quick, easy, cheap, effective, rugged, and safe) dispersive SPE (dSPE) method is an emerging sample preparation technique that is becoming increasingly popular in the area of multi-residue pesticide analysis in food and agricultural products. ... |
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Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014) • The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail. |
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Dynamic high performance liquid chromatography on chiral stationary phases. Low temperature separation of the interconverting enantiomers of diazepam, flunitrazepam, prazepam and tetrazepam.
J. Chromatogr. A. 1363 , 144-9, (2014) Diazepam and the structurally related 1,4-benzodiazepin-2-ones tetrazepam, prazepam and flunitrazepam are chiral molecules because they adopt a ground state conformation featuring a non-planar seven membered ring devoid of any reflection-symmetry element. The... |
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Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the quantitation of prazepam and its main metabolites in human plasma.
J. Mass Spectrom. 40(4) , 516-26, (2005) A method was developed and fully validated for the quantitation of prazepam and its major metabolites, oxazepam and nordiazepam, in human plasma. Sample pretreatment was achieved by solid-phase extraction using Oasis HLB cartridges. The extracts were analysed... |
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A salt-free isocratic high-pressure liquid chromatographic method for the quantitation of benzodiazepines in serum.
Clin. Biochem. 26(3) , 165-71, (1993) A simple, rapid high-pressure liquid chromatography (HPLC) method was developed for detecting and quantifying benzodiazepines in serum. Seven major benzodiazepines were extracted from spiked serum samples using solid-phase extraction with prazepam as the inte... |
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Kinetic study on the degradation of prazepam in acidic aqueous solutions by high-performance liquid chromatography and fourth-order derivative ultraviolet spectrophotometry.
J. Pharm. Biomed. Anal. 17(4-5) , 739-50, (1998) A reversed-phase HPLC method was developed for the kinetic investigation of the acidic hydrolysis of prazepam which was carried out in hydrochloric acid solutions of 0.01, 0.1 and 1.0 M. In addition, a fourth-order derivative method for monitoring the parent ... |
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Compared efficacy of prazepam and clomipramine in major depression with anxiety: a multicenter controlled study.
Pharmacopsychiatry 24(5) , 175-9, (1991) The efficacy of antidepressants is well established in major depressions, especially those with melancholic features. However, some anxiolytics also appear to have antidepressant properties at least for outpatients. 118 outpatients (25 males, 93 females, age:... |
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Development of a supercritical fluid extraction method for the determination of temazepam in whole blood.
J. Anal. Toxicol. 21(4) , 297-300, (1997) A supercritical fluid extraction (SFE) procedure for the analysis of temazepam from whole blood was developed. Quantitative recoveries were obtained by high-performance liquid chromatography using prazepam as an internal standard and carefully monitoring the ... |
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Naltrexone plus benzodiazepine aids abstinence in opioid-dependent patients.
Life Sci. 77(21) , 2717-22, (2005) Naltrexone (NTX) is widely used to prevent relapse of opioid-dependent patients but its association with insomnia and "hyperexcitability" can result in treatment withdrawal. We evaluated whether NTX combined with the benzodiazepine prazepam was more effective... |
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Benzodiazepines prescription in Dakar: a study about prescribing habits and knowledge in general practitioners, neurologists and psychiatrists.
Fundam. Clin. Pharmacol. 20(3) , 235-8, (2006) Benzodiazepines are relatively well-tolerated medicines but can induce serious problems of addiction and that is why their use is regulated. However, in developing countries like Senegal, these products are used without clear indications on their prescription... |