Fenofibric acid
Fenofibric acid structure
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Common Name | Fenofibric acid | ||
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| CAS Number | 42017-89-0 | Molecular Weight | 318.752 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 486.5±35.0 °C at 760 mmHg | |
| Molecular Formula | C17H15ClO4 | Melting Point | 176--179ºC | |
| MSDS | Chinese USA | Flash Point | 248.0±25.9 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Enzymatic characterization of ELOVL1, a key enzyme in very long-chain fatty acid synthesis.
Biochim. Biophys. Acta 1851(2) , 231-7, (2015) X-linked adrenoleukodystrophy (X-ALD) is a neurometabolic disease that is caused by mutations in the ABCD1 gene. ABCD1 protein deficiency impairs peroxisomal very long-chain fatty acid (VLCFA) degradation resulting in increased cytosolic VLCFA-CoA levels, whi... |
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The Lidose hard capsule formulation of fenofibrate is suprabioavailable compared to the nanoparticle tablet formulation under high-fat fed conditions.
J. Pharm. Pharm. Sci. 18(1) , 61-7, (2015) The therapeutic equivalence of multiple registered fenofibrate formulations, several of which are suprabioavailable and therefore marketed at lower dosage strengths than their reference products, is based on the results of bioequivalence studies. Most of thes... |
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Endoplasmic reticulum stress involved in high-fat diet and palmitic acid-induced vascular damages and fenofibrate intervention.
Biochem. Biophys. Res. Commun. 458(1) , 1-7, (2015) Fenofibrate (FF) is widely used to lower blood lipids in clinical practice, but whether its protective effect on endothelium-dependent vasodilatation (EDV) in thoracic aorta is related with endoplasmic reticulum (ER) stress remains unknown. In this study, fem... |
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Effect of fenofibrate and LF 2151 on hepatic peroxisomes in hamsters.
Biochem. Pharmacol. 33(22) , 3661-6, (1984) Hamsters were given a diet containing fenofibrate (0.5% or 0.05%) or its metabolite, LF 2151 (0.15% or 0.015%) or a standard diet for a 3-week period. At the end of this period, the analysis of plasma lipids showed that the mean plasma triglyceride concentrat... |
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Inactivation of 3-hydroxy-3-methylglutaryl coenzyme a reductase in cultured human blood mononuclear cells by procetofenic acid
Pharmacol. Res. Commun. 14(1) , 51-60, (1982) The effect of procetofenic acid on 3-hydroxy-3-methylglutaryl Coenzyme A reductase (HMG-CoA reductase) activity has been studied on cultured human blood mononuclear cells. The drug produced a sharp decrease in enzyme activity both when it was added to the inc... |
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Effects of a salt of cholestyramine and 2-[4-(p-chlorobenzoyl)phenoxy]2-methyl propionic acid (alpha-1081) on biliary lipid secretion in rats.
Br. J. Pharmacol. 74(3) , 611-7, (1981) 1 Hypolipidaemic agents may increase biliary cholesterol in man, inducing a supersaturated bile. 2 To evaluate this possible side-effect, we have studied bile lipid secretion over a period of 8 h with intact enterohepatic circulation and 4 h with complete int... |
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Simple and rapid method for determining procetofenic acid, an active metabolite of procetofen, in biological fluids by solid-phase extraction and high-performance liquid chromatography.
J. Chromatogr. A. 383(2) , 419-24, (1986)
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Rapid determination of procetofenic acid in plasma by high-performance liquid chromatography.
J. Chromatogr. A. 227(1) , 219-22, (1982)
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