4-thiouridine
4-thiouridine structure
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Common Name | 4-thiouridine | ||
|---|---|---|---|---|
| CAS Number | 13957-31-8 | Molecular Weight | 260.267 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C9H12N2O5S | Melting Point | 139-140℃ (ethanol ) | |
| MSDS | Chinese USA | Flash Point | N/A | |
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HIV-1 RNAs are Not Part of the Argonaute 2 Associated RNA Interference Pathway in Macrophages.
PLoS ONE 10 , e0132127, (2015) MiRNAs and other small noncoding RNAs (sncRNAs) are key players in post-transcriptional gene regulation. HIV-1 derived small noncoding RNAs (sncRNAs) have been described in HIV-1 infected cells, but their biological functions still remain to be elucidated. He... |
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Noncapped Alphavirus Genomic RNAs and Their Role during Infection.
J. Virol. 89 , 6080-92, (2015) Alphaviruses are enveloped positive-sense RNA viruses that exhibit a wide host range consisting of vertebrate and invertebrate species. Previously we have reported that the infectivity of Sindbis virus (SINV), the model alphavirus, was largely a function of t... |
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Proteotoxic stress reprograms the chromatin landscape of SUMO modification.
Sci. Signal. 8 , rs7, (2015) The small ubiquitin-like modifier 2 (SUMO-2) is required for survival when cells are exposed to treatments that induce proteotoxic stress by causing the accumulation of misfolded proteins. Exposure of cells to heat shock or other forms of proteotoxic stress i... |
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Synthesis and decay of varicella zoster virus transcripts.
J. Neurovirol. 17(3) , 281-7, (2011) Varicella zoster virus (VZV) is highly cell-associated. At least 68 VZV open reading frames (ORFs) are transcribed in varying amounts that increase as infection progresses. Using reverse transcriptase PCR, quantification of total and newly synthesized mRNA sh... |
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Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism.
J. Clin. Invest. 123(3) , 1216-28, (2013) Chemically modified mRNA is capable of inducing therapeutic levels of protein expression while circumventing the threat of genomic integration often associated with viral vectors. We utilized this novel therapeutic tool to express the regulatory T cell transc... |
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Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC.
BMC Struct. Biol. 13 , 5, (2013) Methylaminomethyl modification of uridine or 2-thiouridine (mnm5U34 or mnm5s2U34) at the wobble position of tRNAs specific for glutamate, lysine and arginine are observed in Escherichia coli and allow for specific recognition of codons ending in A or G. In th... |
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Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma.
Oncotarget 6 , 43182-201, (2016) Despite intensive study, many mysteries remain about the MYCN oncogene's functions. Here we focus on MYCN's role in neuroblastoma, the most common extracranial childhood cancer. MYCN gene amplification occurs in 20% of cases, but other recurrent somatic mutat... |
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Transcription-coupled RNA surveillance in human genetic diseases caused by splice site mutations.
Hum. Mol. Genet. 24 , 2784-95, (2015) Current estimates indicate that approximately one-third of all disease-causing mutations are expected to disrupt splicing. Abnormal splicing often leads to disruption of the reading frame with introduction of a premature termination codon (PTC) that targets t... |
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Deciphering the modulation of gene expression by type I and II interferons combining 4sU-tagging, translational arrest and in silico promoter analysis.
Nucleic Acids Res. 41(17) , 8107-25, (2013) Interferons (IFN) play a pivotal role in innate immunity, orchestrating a cell-intrinsic anti-pathogenic state and stimulating adaptive immune responses. The complex interplay between the primary response to IFNs and its modulation by positive and negative fe... |
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The tRNA thiolation pathway modulates the intracellular redox state in Escherichia coli.
J. Bacteriol. 195(9) , 2039-49, (2013) We have performed a screening of hydroxyurea (HU)-sensitive mutants using a single-gene-deletion mutant collection in Escherichia coli K-12. HU inhibits ribonucleotide reductase (RNR), an enzyme that catalyzes the formation of deoxyribonucleotides. Unexpected... |