Cornuside
Cornuside structure
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Common Name | Cornuside | ||
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| CAS Number | 131189-57-6 | Molecular Weight | 542.487 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 817.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C24H30O14 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 274.5±27.8 °C | |
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[Optimization of microwave-assisted extraction with RSM and HPLC determination for three iridoid glycosides in Cornus officinalis].
Zhong Yao Cai 34(7) , 1118-22, (2011) To establish a method of microwave-assisted extraction and high performance liquid chromatographic (HPLC) for simultaneous determination of three iridoid glycosides including loganin, sweroside and cornuside in Cornus officinalis. |
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Simultaneous determination of six active components in crude and processed Fructus Corni by high performance liquid chromatography.
J. Pharm. Biomed. Anal. 48(1) , 194-7, (2008) A simple and rapid HPLC method was established for simultaneously determining six active components in Fructus Corni. The six components were separated on an Agilent Zorbax Extend C18 column (250 mmx4.6 mm, 5 microm) and detected by diode array detector (DAD)... |
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[Studies on the chemical constituents of Cornus officinalis Sieb et Zucc].
Yao Xue Xue Bao 27(11) , 845-8, (1992) A new bisiridoid glucoside named cornuside was isolated from the fruits of Cornus officinalis Sieb et Zucc. The structure of cornuside has been established by spectroscopic methods (IR, MS, 1HNMR, 13CNMR). |
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Protective roles of cornuside in acute myocardial ischemia and reperfusion injury in rats.
Phytomedicine 18(4) , 266-71, (2011) Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis SIEB. et ZUCC. In this study, we investigated the anti-myocardial ischemia and reperfusion (I/R) injury effects of cornuside in vivo and elucidated the potential mechanism. Rat... |
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Endothelial NO/cGMP-dependent vascular relaxation of cornuside isolated from the fruit of Cornus officinalis.
Planta Med. 73(14) , 1436-40, (2007) Cornuside is a bisiridoid glucoside compound isolated from the fruit of CORNUS OFFICINALIS Sieb. et Zucc. (Cornaceae). In the present study, we investigated the effect of cornuside on vascular tone in rat aortic tissue. Cornuside induced a concentration-depen... |
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Protective effect of cornuside against carbon tetrachloride-induced acute hepatic injury.
Biosci. Biotechnol. Biochem. 75(4) , 656-61, (2011) This study elucidated the effects of cornuside on carbon tetrachloride (CCl₄)-induced hepatotoxicity. Rats were treated intraperitoneally with 0.5 mL/kg of CCl₄. Sixteen h after CCl₄ treatment, the levels of serum aminotransferases, tumor necrosis factor-α (T... |
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Cornuside suppresses cytokine-induced proinflammatory and adhesion molecules in the human umbilical vein endothelial cells.
Biol. Pharm. Bull. 30(9) , 1796-9, (2007) Cornuside is a bisiridoid glucoside compound isolated from the fruit of Cornus officinalis SIEB. et ZUCC. The present study was designed to examine the effects of cornuside on expression levels of cytokine-induced proinflammatory and adhesion molecules in the... |
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Effect of cornuside on experimental sepsis.
Planta Med. 75(6) , 614-9, (2009) This study was conducted to investigate the efficacy of cornuside, a secoiridoid glucoside compound, in cultured macrophages as well as in an experimental model of sepsis induced by cecal ligation and puncture (CLP) in rats. Cornuside was added to cultured ma... |
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Cornuside suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting nuclear factor-kappa B activation in RAW 264.7 macrophages.
Biol. Pharm. Bull. 34(7) , 959-66, (2011) Cornuside, a secoiridoid glucoside compound, was isolated from the fruit of Cornus officinalis SIEB. et ZUCC. Cornuside has been reported to possess immunomodulatory and anti-inflammatory activities. However, the effects and mechanism of action of cornuside i... |
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Cornuside attenuates apoptosis and ameliorates mitochondrial energy metabolism in rat cortical neurons.
Pharmacology 84(3) , 162-70, (2009) Cornuside, a secoiridoid glucoside compound, was isolated from the fruit of Cornus officinalis Sieb. et Zucc. The present study elucidates the effects of cornuside on cultured rat cortical neuron damage induced by oxygen-glucose deprivation. The results show ... |