Veratridine
Veratridine structure
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Common Name | Veratridine | ||
|---|---|---|---|---|
| CAS Number | 71-62-5 | Molecular Weight | 673.79000 | |
| Density | 1.45 g/cm3 | Boiling Point | 814.5ºC at 760 mmHg | |
| Molecular Formula | C36H51NO11 | Melting Point | 180ºC | |
| MSDS | Chinese USA | Flash Point | 446.4ºC | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Ikarisoside A inhibits acetylcholine-induced catecholamine secretion and synthesis by suppressing nicotinic acetylcholine receptor-ion channels in cultured bovine adrenal medullary cells.
Naunyn Schmiedebergs Arch. Pharmacol. 388 , 1259-69, (2015) Ikarisoside A is a natural flavonol glycoside derived from plants of the genus Epimedium, which have been used in Traditional Chinese Medicine as tonics, antirheumatics, and aphrodisiacs. Here, we report the effects of ikarisoside A and three other flavonol g... |
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Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies).
Environ. Res. 143 , 100-8, (2015) From 2010 to 2012, 35 ciguatera fish poisoning (CFP) events involving 87 individuals who consumed locally-caught fish were reported in Guadeloupe (French West Indies). For 12 of these events, the presence of ciguatoxins (CTXs) was indicated in meal remnants a... |
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Voltage-activated calcium channels involved in veratridine-evoked [3H]dopamine release in rat striatal slices.
Neuropharmacology 37 , 973-982, (1998) The present study explored the role of different sub-types of voltage-activated Ca2+ channels (VACCs) in mediating veratridine-evoked [3H]dopamine (DA) release from rat striatal slices. The release of [3H]DA evoked by veratridine (25 microM) decreased by 50.6... |
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Antimetastatic potential of amide-linked local anesthetics: inhibition of lung adenocarcinoma cell migration and inflammatory Src signaling independent of sodium channel blockade.
Anesthesiology 117(3) , 548-59, (2012) Retrospective analysis of patients undergoing cancer surgery suggests the use of regional anesthesia may reduce cancer recurrence and improve survival. Amide-linked local anesthetics have antiinflammatory properties, although the mechanism of action in this r... |
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QuEChERS approach for the determination of biopesticides in organic and nonorganic vegetables and fruits by ultra-performance liquid chromatography/tandem mass spectrometry.
J. AOAC Int. 97(4) , 1027-33, (2014) A method for the determination of 14 biopesticides and piperonyl butoxide (PBO), often applied in organic farming, in vegetables and fruits has been developed. Extraction was performed using the Quick, Easy, Cheap, Effective, Rugged, and Safe method, and the ... |
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Neurotransmitter regulation of c-fos and vasopressin gene expression in the rat supraoptic nucleus.
Exp. Neurol. 219 , 212-22, (2009) Acute increases in plasma osmotic pressure produced by intraperitoneal injection of hypertonic NaCl are sensed by osmoreceptors in the brain, which excite the magnocellular neurons (MCNs) in the supraoptic nucleus (SON) and the paraventricular nucleus (PVN) i... |
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Inversion of Sonic hedgehog action on its canonical pathway by electrical activity.
Proc. Natl. Acad. Sci. U. S. A. 112(13) , 4140-5, (2015) Sonic hedgehog (Shh) is a morphogenic protein that operates through the Gli transcription factor-dependent canonical pathway to orchestrate normal development of many tissues. Because aberrant levels of Gli activity lead to a wide spectrum of diseases ranging... |
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Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin.
J. Cell Biol. 206(5) , 655-70, (2014) To minimize oxidative damage to the cell, malfunctioning mitochondria need to be removed by mitophagy. In neuronal axons, mitochondrial damage may occur in distal regions, far from the soma where most lysosomal degradation is thought to occur. In this paper, ... |
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Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profiling.
ACS Chem. Neurosci. 6 , 871-8, (2015) Ion channels are critical for life, and they are targets of numerous drugs. The sequencing of the human genome has revealed the existence of hundreds of different ion channel subunits capable of forming thousands of ion channels. In the face of this diversity... |
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Effects of antiepileptic drugs on GABA release from rat and human neocortical synaptosomes.
Naunyn Schmiedebergs Arch. Pharmacol. 384(1) , 47-57, (2011) In epilepsy, allegedly, a neurotransmitter imbalance between the inhibitory GABA and the excitatory glutamate prevails. Therefore, some antiepileptic drugs (AEDs) are thought to increase GABA release. Because little is known about corresponding presynaptic ef... |