[4-(1H-Tetrazol-5-Yl)Phenyl]Boronic Acid

[4-(1H-Tetrazol-5-Yl)Phenyl]Boronic Acid Structure
[4-(1H-Tetrazol-5-Yl)Phenyl]Boronic Acid structure
Common Name [4-(1H-Tetrazol-5-Yl)Phenyl]Boronic Acid
CAS Number 179942-55-3 Molecular Weight 189.96700
Density 1.51g/cm3 Boiling Point 480.3ºC at 760mmHg
Molecular Formula C7H7BN4O2 Melting Point N/A
MSDS Chinese USA Flash Point 244.2ºC

Discovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors.

Bioorg. Med. Chem. Lett. 21 , 6793-6799, (2011)

We report here the discovery of a novel series of selective mTOR kinase inhibitors. A series of imidazo[4,5-b]pyrazin-2-ones, represented by screening hit 1, was developed into lead compounds with excellent mTOR potency and exquisite kinase selectivity. Poten...