L-Albizziin
L-Albizziin structure
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Common Name | L-Albizziin | ||
|---|---|---|---|---|
| CAS Number | 1483-07-4 | Molecular Weight | 147.13300 | |
| Density | 1.43 g/cm3 | Boiling Point | 359.1ºC at 760 mmHg | |
| Molecular Formula | C4H9N3O3 | Melting Point | 217°C (dec.) | |
| MSDS | Chinese USA | Flash Point | 171ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Molecular and genetic characterization of human cell lines resistant to L-asparaginase and albizziin.
Somat. Cell Mol. Genet. 16(1) , 59-65, (1990) Human cell lines resistant to L-asparaginase or albizziin were isolated by multistep selection of HT1080 fibrosarcoma and MIA PaCa-2 pancreatic carcinoma cells. Mutants were cross-resistant to both drugs, but more resistant to the drug used for selection. The... |
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Chromosomal alterations associated with overproduction of asparagine synthetase in albizziin-resistant Chinese hamster ovary cells.
Mol. Cell. Biol. 3(3) , 391-8, (1983) The amino acid analog albizziin was used to isolate Chinese hamster ovary cell lines which overproduce asparagine synthetase. Mutants selected in a single step after ethyl methane sulfonate mutagenesis were approximately 10-fold more resistant to the drug tha... |
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Use of the Escherichia coli gene for asparagine synthetase as a selective marker in a shuttle vector capable of dominant transfection and amplification in animal cells.
Mol. Cell. Biol. 7(5) , 1623-8, (1987) A new dominant amplifiable selective system for use in bacterium-animal cell shuttle vectors was developed by the insertion of a 2-kilobase genomic fragment containing the cloned Escherichia coli gene for asparagine synthetase (AS) into the pBR322-simian viru... |
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Overexpression of asparagine synthetase in albizziin-resistant murine diploid embryonic stem cells.
Somat. Cell Mol. Genet. 19(4) , 321-30, (1993) Gene amplification is commonly observed in primary tumors and established drug-resistant cell lines, both of which are generally aneuploid. However, this process is undetectable (frequency < 10(-9) in normal diploid mammalian cell lines. To investigate whethe... |
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Characterization of single step albizziin-resistant Chinese hamster ovary cell lines with elevated levels of asparagine synthetase activity.
J. Biol. Chem. 260(12) , 7523-7, (1985) The amino acid analog, albizziin, which acts as a competitive inhibitor of asparagine synthetase with respect to glutamine was used to isolate mutants of Chinese hamster ovary cells with alterations in levels of the target enzyme. These mutant lines have been... |
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Effects of intermediary metabolites and electron transport inhibitors on action of chloroquine on Brugia pahangi and Onchocerca volvulus.
Biochem. Pharmacol. 38(23) , 4327-32, (1989) We examined the possibility that chloroquine is interfering with aerobic energy-generating processes in the adult filarial parasites, Brugia pahangi and Onchocerca volvulus. Using motility of these parasites as an assay of drug effect, we found that micromola... |
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High-affinity glutamine uptake of the rat hippocampus during postnatal development: a quantitative autoradiographic study.
Neuroscience 34(1) , 49-55, (1990) Glutamine uptake into hippocampal slices of the rat was investigated autoradiographically. The characteristics of registered [14C]glutamine uptake such as the incubation with the radiolabelled amino acid at a concentration of 3.5 mumol/l, sodium dependency, t... |