Isomalathion
Isomalathion structure
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Common Name | Isomalathion | ||
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| CAS Number | 3344-12-5 | Molecular Weight | 330.35800 | |
| Density | 1.273g/cm3 | Boiling Point | 413.6ºC at 760mmHg | |
| Molecular Formula | C10H19O6PS2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 203.9ºC | |
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Probing the chiral separation mechanism and the absolute configuration of malathion, malaoxon and isomalathion enantiomers by chiral high performance liquid chromatography coupled with chiral detector-binding energy computations.
J. Chromatogr. A. 1281 , 26-31, (2013) Chiral separation mechanism determination and absolute configuration assignment are fundamental to the development of chiral stationary phases (CSPs) and the evaluation of both the enantioselective bioactivity and fate of chiral compounds. This work investiga... |
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Comparison of photocatalysis and photolysis of malathion, isomalathion, malaoxon, and commercial malathion--products and toxicity studies.
Water Res. 41(19) , 4504-14, (2007) Malathion, one of the most widely applied insecticides, is still used in agriculture. There are many studies regarding its degradation under different experimental conditions, but few deal with its transformation products, i.e. malaoxon and isomalathion. Thus... |
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An enzyme test for determining isomalathion impurities in water-dispersible powders of malathion.
Bull. World Health Organ. 64(3) , 397-401, (1986) An enzyme test for determining isomalathion (O,S-dimethyl-S-(1,2-dicarbethoxyethyl) phosphorodithioate) impurities in water-dispersible powders of malathion (WDP malathion) is described. The test is based on inhibition of acetylcholinesterase (EC 3.1.1.7) by ... |
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Toxicological properties of trialkyl phosphorothioate and dialkyl alkyl- and arylphosphonothioate esters.
J. Environ. Sci. Health B 18(1) , 89-117, (1983) Impurities such as O,S,S-trimethyl phosphorodithioate (TMPD) and the S-methyl isomer of malathion (isomalathion) strongly potentiated the mammalian toxicity of malathion. In contrast, impurities present in the phosphoramidothioate insecticide acephate had an ... |
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Malathion detoxification by human hepatic carboxylesterases and its inhibition by isomalathion and other pesticides.
J. Biochem. Mol. Toxicol. 19(6) , 406-14, (2005) The organophosphorothioate (OPT) pesticide malathion (MAL) in mammals is readily hydrolyzed by mammalian carboxylesterases (CE). The reaction competes with the CYP-catalyzed formation of malaoxon (MOX), the toxic metabolite. Alterations or individual variatio... |
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Interaction of some trialkyl phosphorothiolates with acetylcholinesterase. Characterization of inhibition, aging and reactivation.
Biochim. Biophys. Acta 660(2) , 306-16, (1981) The reaction of bovine erythrocyte acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) with a set of structurally related phosphorothiolates was studied in order to investigate the properties of the phosphorylated enzymes and to identify the leav... |
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Synthesis, absolute configuration, and analysis of malathion, malaoxon, and isomalathion enantiomers.
Chem. Res. Toxicol. 6(5) , 718-23, (1993) Syntheses of the enantiomers of malathion, malaoxon, and isomalathion are reported herein. Malathion enantiomers were prepared from (R)- or (S)-malic acid in three steps. Enantiomers of malathion were converted to the corresponding enantiomers of malaoxon in ... |
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Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry.
Toxicol. Sci. 100(1) , 136-45, (2007) Some organophosphorus compounds are toxic because they inhibit acetylcholinesterase (AChE) by phosphylation of the active site serine, forming a stable conjugate: Ser-O-P(O)-(Y)-(XR) (where X can be O, N, or S and Y can be methyl, OR, or SR). The inhibited en... |
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Interaction of acetylcholinesterase with the enantiomers of malaoxon and isomalathion.
Chem. Res. Toxicol. 6(5) , 724-30, (1993) The biomolecular reaction constants (ki), dissociation constants (Kd), and phosphorylation constants (kp) were determined for the enantiomers of malaoxon against rat brain acetylcholinesterase, and for the stereoisomers of isomalathion against rat brain acety... |
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Inhibition of acetylcholinesterase by (1S,3S)-isomalathion proceeds with loss of thiomethyl: kinetic and mass spectral evidence for an unexpected primary leaving group.
Chem. Res. Toxicol. 13(12) , 1313-20, (2000) Previous work demonstrated kinetically that inhibition of mammalian acetylcholinesterase (AChE) by (1S)-isomalathions may proceed by loss of thiomethyl instead of the expected diethyl thiosuccinate as the primary leaving group followed by one of four possible... |