Bromocyclobutane

Bromocyclobutane Structure
Bromocyclobutane structure
Common Name Bromocyclobutane
CAS Number 4399-47-7 Molecular Weight 135.002
Density 1.6±0.1 g/cm3 Boiling Point 107.1±9.0 °C at 760 mmHg
Molecular Formula C4H7Br Melting Point N/A
MSDS Chinese USA Flash Point 22.2±0.0 °C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger

Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3.

J. Med. Chem. 48 , 6169, (2005)

A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P1) receptor agonists with minimal affinity for the S1P2 and S1P3 receptor subtypes. Analogue 26 (S1P1 IC50 = 0.6 nM) has an excellent pharmac...

Photodissociation of cyclobutyl bromide at 234 nm studied using velocity map imaging.

J. Phys. Chem. A 110(16) , 5379-85, (2006)

This study investigates the 234 nm photodissociation dynamics of cyclobutyl bromide using a two-dimensional photofragment velocity imaging technique. The spin-orbit ground- and excited-state Br(2P) atoms are state-selectively detected via [2+1] resonance enha...

Discovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis.

Bioorg. Med. Chem. Lett. 15 , 3696, (2005)

An encoded combinatorial library based on aryl and biaryl piperidine scaffolds was designed and synthesized. Screening of this library resulted in the discovery of high-nanomolar biaryl piperidine-based MCH1 receptor antagonists. Follow-up optimization using ...