Reversine
Reversine structure
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Common Name | Reversine | ||
|---|---|---|---|---|
| CAS Number | 656820-32-5 | Molecular Weight | 393.485 | |
| Density | 1.343±0.06 g/cm3 | Boiling Point | 736.4±70.0 °C at 760 mmHg | |
| Molecular Formula | C21H27N7O | Melting Point | 305 ºC (decomp) | |
| MSDS | Chinese USA | Flash Point | 399.2±35.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20.
J. Cell Sci. 128(8) , 1639-53, (2015) Nek2 isoform A (Nek2A) is a presumed substrate of the anaphase-promoting complex/cyclosome containing Cdc20 (APC/C(Cdc20)). Nek2A, like cyclin A, is degraded in mitosis while the spindle checkpoint is active. Cyclin A prevents spindle checkpoint proteins from... |
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Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression.
EMBO Rep. 17 , 414-27, (2016) E2F transcription factors control the oscillating expression pattern of multiple target genes during the cell cycle. Activator E2Fs, E2F1-3, induce an upswing of E2F targets, which is essential for the G1-to-S phase transition, whereas atypical E2Fs, E2F7 and... |
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Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.
Nat. Commun. 6 , 8399, (2015) Warsaw breakage syndrome (WABS) is caused by defective DDX11, a DNA helicase that is essential for chromatid cohesion. Here, a paired genome-wide siRNA screen in patient-derived cell lines reveals that WABS cells do not tolerate partial depletion of individua... |