1-Docosanol
1-Docosanol structure
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Common Name | 1-Docosanol | ||
|---|---|---|---|---|
| CAS Number | 661-19-8 | Molecular Weight | 326.600 | |
| Density | 0.8±0.1 g/cm3 | Boiling Point | 375.9±5.0 °C at 760 mmHg | |
| Molecular Formula | C22H46O | Melting Point | 65-72 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 142.5±5.2 °C | |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Surface properties of artificial tear film lipid layers: effects of wax esters.
Invest. Ophthalmol. Vis. Sci. 55(7) , 4448-54, (2014) The tear film lipid layer is believed to stabilize the tear film and to retard evaporation. Based on previous simple in vitro studies, the evidence for the latter property is scarce. In this study, we used complex lipid mixtures including various wax esters t... |
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Bioactive constituents in Prunus africana: geographical variation throughout Africa and associations with environmental and genetic parameters.
Phytochemistry 83 , 70-8, (2012) Prunus africana--an evergreen tree found in Afromontane forests--is used in traditional medicine to cure benign prostate hyperplasia. Different bioactive constituents derived from bark extracts from 20 tree populations sampled throughout the species' natural ... |
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Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening.
Drug Des. Devel. Ther. 9 , 3313-24, (2015) Cholesterol plays an important role in living cells. However, a very high level of cholesterol may lead to atherosclerosis. HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase is the key enzyme in the cholesterol biosynthesis pathway, and the statin-lik... |
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Rapid sampling of molecules via skin for diagnostic and forensic applications.
Pharm. Res. 27(7) , 1255-63, (2010) Skin provides an excellent portal for diagnostic monitoring of a variety of entities; however, there is a dearth of reliable methods for patient-friendly sampling of skin constituents. This study describes the use of low-frequency ultrasound as a one-step met... |
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Docosanol: a topical antiviral for herpes labialis.
Expert Opin. Pharmacother. 5(12) , 2567-71, (2004) Recurrent herpes labialis is a painful and potentially disfiguring infection affecting an estimated 40 million people in the US alone. The majority of recurrences are caused by herpes simplex virus type 1. Various oral and topical formulations of nucleoside a... |
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epicuticle lipids mediate mate recognition in Triatoma infestans.
J. Chem. Ecol. 37(3) , 246-52, (2011) Epicuticular lipids are contact cues in intraspecific chemical communication in insects, both for aggregation and sexual behavior. Triatomine bugs are vectors of the parasite Trypanosoma cruzi, the cause of Chagas disease. In Triatoma infestans, the major epi... |
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Weak first-order tilting transition in monolayers of mono- and bipolar docosanol derivatives.
J. Phys. Chem. B 110(44) , 22237-44, (2006) A systematic analysis of pressure-area isotherms and grazing incidence X-ray diffraction (GIXD) data of 22-methoxydocosan-1-ol (H3C-O-(CH2)22-OH, MDO), docosan-1-ol (H3C-(CH2)21-OH, DO), and docosyl methyl ether (H3C-(CH2)21-O-CH3, DME) monolayers on pure wat... |
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α-gel prepared in sodium methyl stearoyl taurate/behenyl alcohol/water system-characterization of structural changes with water concentration.
J. Oleo Sci. 61(1) , 29-34, (2012) In this study, the changes in the structural and physicochemical properties of an α-crystalline phase (often called an "α-gel") were assessed in a sodium methyl stearoyl taurate (SMT)/behenyl alcohol/water system. The α-gels were characterized focusing on the... |
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Treatment of herpes labialis: comparison of two OTC drugs and untreated controls.
J. Esthet. Restor. Dent. 24(2) , 103-9, (2012) Rapid resolution of active herpes labialis lesions is of great benefit to the patient not only in terms of controlling pain and disfigurement, but in disruption of needed dental treatment.Using three groups, this retrospective study investigated the time requ... |