1-Docosanol

Modify Date: 2024-01-02 13:12:36

1-Docosanol Structure
1-Docosanol structure
 Common Name 1-Docosanol
CAS Number 661-19-8 Molecular Weight 326.600
Density 0.8±0.1 g/cm3 Boiling Point 375.9±5.0 °C at 760 mmHg
Molecular Formula C22H46O Melting Point 65-72 °C(lit.)
MSDS Chinese USA Flash Point 142.5±5.2 °C

 Use of 1-Docosanol


1-Docosanol is a saturated fatty alcohol used traditionally as an emollient, emulsifier, and thickener in cosmetics, and nutritional supplement; inhibitor of lipid-enveloped viruses including herpes simplex.

 Names

Name 1-Docosanol
Synonym More Synonyms

 1-Docosanol Biological Activity

Description 1-Docosanol is a saturated fatty alcohol used traditionally as an emollient, emulsifier, and thickener in cosmetics, and nutritional supplement; inhibitor of lipid-enveloped viruses including herpes simplex.
Related Catalog
References

[1]. Katz DH, et al. Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10825-9.

[2]. Sacks SL, et al. Clinical efficacy of topical docosanol 10% cream for herpes simplex labialis: A multicenter, randomized, placebo-controlled trial. J Am Acad Dermatol. 2001 Aug;45(2):222-30.

 Chemical & Physical Properties

Density 0.8±0.1 g/cm3
Boiling Point 375.9±5.0 °C at 760 mmHg
Melting Point 65-72 °C(lit.)
Molecular Formula C22H46O
Molecular Weight 326.600
Flash Point 142.5±5.2 °C
Exact Mass 326.354858
PSA 20.23000
LogP 10.44
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.455
Storage condition 2-8°C
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility Insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JR1315000
CHEMICAL NAME :
1-Docosanol
CAS REGISTRY NUMBER :
661-19-8
BEILSTEIN REFERENCE NO. :
1770470
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C22-H46-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,879,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,879,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,879,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T2018 No. of Facilities: 151 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1358 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany -
RTECS JR1315000
HS Code 29051900

 Synthetic Route

 Customs

HS Code 29051900

 Articles31

More Articles
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...
Surface properties of artificial tear film lipid layers: effects of wax esters.

Invest. Ophthalmol. Vis. Sci. 55(7) , 4448-54, (2014)

The tear film lipid layer is believed to stabilize the tear film and to retard evaporation. Based on previous simple in vitro studies, the evidence for the latter property is scarce. In this study, we...
Bioactive constituents in Prunus africana: geographical variation throughout Africa and associations with environmental and genetic parameters.

Phytochemistry 83 , 70-8, (2012)

Prunus africana--an evergreen tree found in Afromontane forests--is used in traditional medicine to cure benign prostate hyperplasia. Different bioactive constituents derived from bark extracts from 2...

 Synonyms

Emery 3304
MFCD00002939
Docosanol
ALCOHOL C22
tadenan
lidavol
IK 2 (alcohol)
n-docosanol
behenic alcohol
Docosanol (Abreua)
behenyl alcohol
ik2
docosanyl alcohol
docosan-1-ol
Abreva
Lidakol
1-Docosanol
EINECS 211-546-6
JARCOL 22
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Related Compounds: More...
1-DOCOSANOL
1599-67-3
1-Docosanol,TMS
42449-18-3
1-Docosanol formate
15155-62-1
1-docosanol acetate
822-26-4
1-Docosanol,benzoate
103403-38-9
22-bromo-1-docosanol
91146-02-0
1-Docosanol,phosphate
76930-22-8
1-DOCOSANOL,PHOSPHATE
64131-09-5
1-Docosanol propanoate
55334-75-3
Chemsrc provides 1-Docosanol(CAS#:661-19-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 1-Docosanol are included as well.>> amp version: 1-Docosanol

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