1-Benzylpiperazine dihydrochloride
1-Benzylpiperazine dihydrochloride structure
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Common Name | 1-Benzylpiperazine dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 5321-63-1 | Molecular Weight | 249.180 | |
| Density | 1.025g/cm3 | Boiling Point | 291.1ºC at 760 mmHg | |
| Molecular Formula | C11H18Cl2N2 | Melting Point | 289-292ºC | |
| MSDS | N/A | Flash Point | 119.9ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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An analysis of legal highs: do they contain what it says on the tin?
Drug Test. Anal. 3(9) , 576-81, (2011) In recent years the availability of so-called legal highs over the Internet has hugely increased. Numerous online legal-high retailers market a broad variety of products which are advertised as research chemicals, bath salts, or plant food although clearly in... |
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Validation of an LC-MS method for the detection and quantification of BZP and TFMPP and their hydroxylated metabolites in human plasma and its application to the pharmacokinetic study of TFMPP in humans.
J. Forensic Sci. 55(5) , 1311-8, (2010) An LC-MS method was developed for benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP), constituents of "party pills" or "legal herbal highs," and their metabolites in human blood plasma. Compounds were resolved using a mixture of ammonium forma... |
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Metabolic interactions with piperazine-based 'party pill' drugs.
J. Pharm. Pharmacol. 61(7) , 877-82, (2009) 'Party pills' have found use worldwide as a substitute for amphetamine-derived designer drugs. Whilst some information exists about the metabolism of these drugs, there is little information about their ability to inhibit the metabolism of co-administered dru... |
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Differences in harm from legal BZP/TFMPP party pills between North Island and South Island users in New Zealand: a case of effective industry self-regulation?
Int. J. Drug Policy 21(1) , 86-90, (2010) 'Party' pills containing benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) were sold legally in New Zealand until early 2008. Prospective studies of hospital emergency department admissions appeared to suggest that the harm from party pills w... |
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Current awareness of piperazines: pharmacology and toxicology.
Drug Test. Anal. 3(7-8) , 430-8, (2011) Although many piperazine derivatives exist, only a limited number have been studied, whereby they have been found to be generally stimulant in nature resulting from dopaminergic, noradrenergic, and predominantly serotoninergic effects in the brain. Reported t... |
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Patterns of benzylpiperazine/trifluoromethylphenylpiperazine party pill use and adverse effects in a population sample in New Zealand.
Drug Alcohol Rev. 27(6) , 633-9, (2008) A large legal market for party pills containing benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) developed in New Zealand after 2004. The use of these party pills has been associated with adverse health effects. The purpose of this paper was... |
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Estrogenic effects and their action mechanism of the major active components of party pill drugs.
Toxicol. Lett. 214(3) , 339-47, (2012) Benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) are commonly used constituents of party pill drugs. They are reported to induce psychoactive effects such as euphoria and provide effects similar with other illicit drugs such as methylenediox... |
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Determining the subjective and physiological effects of BZP combined with TFMPP in human males.
Psychopharmacology 214(3) , 761-8, (2011) ‘Party Pills’ containing benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) have been used in a recreational context since the 1990s and, prior to April 2008, were legally available in New Zealand. Taken together, they have been reported to pr... |
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The clinical toxicology of the designer "party pills" benzylpiperazine and trifluoromethylphenylpiperazine.
Clin. Toxicol. (Phila.) 49(3) , 131-41, (2011) Benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) are synthetic phenylpiperazine analogues. BZP was investigated as a potential antidepressant in the early 1970s but was found unsuitable for this purpose. More recently, BZP and TFMPP have bee... |
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Pharmaceutical quality of "party pills" raises additional safety concerns in the use of illicit recreational drugs.
N. Z. Med. J. 126(1376) , 61-70, (2013) To determine the content and release kinetics of 1-benzylpiperazine (BZP) and 1-(3-trifluoromethyl-phenyl)piperazine (TFMPP) from "party pill" formulations. From these data, the possible impact of pharmaceutical quality upon the safety of such illicit formula... |