Oxoadipic acid
Oxoadipic acid structure
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Common Name | Oxoadipic acid | ||
|---|---|---|---|---|
| CAS Number | 3184-35-8 | Molecular Weight | 160.12500 | |
| Density | 1.405g/cm3 | Boiling Point | 364.3ºC at 760mmHg | |
| Molecular Formula | C6H8O5 | Melting Point | 123-125ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 188.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.
Clin. Chem. 40(6) , 862-6, (1994) Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days to 16 years, subdivided into five age groups. We quantifie... |
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The urinary ratio of 3-hydroxykynurenine/3-hydroxyanthranilic acid is an index to predicting the adverse effects of D-tryptophan in rats.
J. Nutr. Sci. Vitaminol. 60(4) , 261-8, (2014) The adverse effects of D-tryptophan and the possibility of it being a surrogate index for predicting adverse effects in rats were investigated. Male rats were fed one of several test diets (20% casein diets with 0% (control), 0.1%, 0.2%, 0.3%, 0.4%, and 0.5% ... |
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Time-dependent effects of L-tryptophan administration on urinary excretion of L-tryptophan metabolites.
J. Nutr. Sci. Vitaminol. 60(4) , 255-60, (2014) We have previously reported that dietary supplementation with up to 5.0 g/d of L-tryptophan (L-Trp) for 21 d has no adverse effects, judging from the levels of general blood variables, in healthy women. We performed a randomized, double-blind, placebo-control... |
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Substrate specificity of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum: toward a bio-based production of adipic acid.
Biochemistry 50(17) , 3540-50, (2011) Expression of six genes from two glutamate fermenting clostridia converted Escherichia coli into a producer of glutaconate from 2-oxoglutarate of the general metabolism (Djurdjevic, I. et al. 2010, Appl. Environ. Microbiol.77, 320-322). The present work exami... |
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Enzyme redesign guided by cancer-derived IDH1 mutations.
Nat. Chem. Biol. 8(11) , 887-9, (2012) Mutations in an enzyme can result in a neomorphic catalytic activity in cancers. We applied cancer-associated mutations from isocitrate dehydrogenases to homologous residues in the active sites of homoisocitrate dehydrogenases to derive enzymes that catalyze ... |
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Identification of N-acetyl-alpha-aminoadipic acid in the urine of a patient with alpha-aminoadipic and alpha-ketoadipic aciduria.
J. Inherit. Metab. Dis. 16(1) , 119-26, (1993) A 3.5-year-old Japanese boy with a mild speech disturbance excreted a large amount of alpha-aminoadipic acid into the urine. The amino acid analysis using an amino acid analyser confirmed the presence of alpha-aminoadipic acid in both urine and plasma. We det... |
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DHTKD1 mutations cause 2-aminoadipic and 2-oxoadipic aciduria.
Am. J. Hum. Genet. 91(6) , 1082-7, (2012) Abnormalities in metabolite profiles are valuable indicators of underlying pathologic conditions at the molecular level. However, their interpretation relies on detailed knowledge of the pathways, enzymes, and genes involved. Identification and characterizati... |
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Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal location.
J. Biol. Chem. 276(11) , 8225-30, (2001) In Saccharomyces cerevisiae, the genes ODC1 and ODC2 encode isoforms of the oxodicarboxylate carrier. They both transport C5-C7 oxodicarboxylates across the inner membranes of mitochondria and are members of the family of mitochondrial carrier proteins. Ortho... |
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Gas chromatographic-mass spectrometric screening for organic acidemias using dried urine filter paper: determination of alpha-ketoacids.
J. Chromatogr. B. Biomed. Sci. Appl. 758(1) , 87-94, (2001) There are several organic acid disorders that require information on alpha-ketoacids, such as maple syrup urine disease or alpha-ketoadipic acidemia. The recovery, stability and diagnostic availability of alpha-ketoacids in dried urine filter paper analyzed b... |
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Homoisocitrate dehydrogenase from Candida albicans: properties, inhibition, and targeting by an antifungal pro-drug.
FEMS Yeast Res. 13(2) , 143-55, (2013) The LYS12 gene from Candida albicans, coding for homoisocitrate dehydrogenase was cloned and expressed as a His-tagged protein in Escherichia coli. The purified gene product catalyzes the Mg(2+)- and K(+)-dependent oxidative decarboxylation of homoisocitrate ... |